Tbio PRKRA Interferon-inducible double-stranded RNA-dependent protein kinase activator A

Protein Summary

Description

Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

Uniprot Accession IDs

• O75569
• A8K3I6
• Q53G24
• Q6X7T5
• Q8NDK4

Gene Name

• PRKRA

Ensembl ID

• ENST00000325748
• ENSP00000318176
• ENSG00000180228
• ENST00000432031
• ENSP00000393883
• ENST00000487082
• ENSP00000430604

Symbol

• PACT
• RAX
• RAX
• PACT
• DYT16
• HSD14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
histone modification site profile	0.78
biological process	0.7
tissue sample	0.69
interacting protein	0.68

Protein Classes

DTO Classes

Protein / Kinase / Unclassified Protein / Interferon-inducible Double-stranded Rna-dependent Protein Kinase Activator A

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.48   (req: < 5)

Gene RIFs: 64   (req: <= 3)

Antibodies: 350   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.48   (req: >= 5)

Gene RIFs: 64   (req: > 3)

Antibodies: 350   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0