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Tbio
PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

Protein Summary
Description
Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325748
  • ENSP00000318176
  • ENSG00000180228
  • ENST00000432031
  • ENSP00000393883
  • ENST00000487082
  • ENSP00000430604

Symbol
  • PACT
  • RAX
  • RAX
  • PACT
  • DYT16
  • HSD14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
histone modification site profile
0.78
biological process
0.7
tissue sample
0.69
interacting protein
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.09   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 350   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.09   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 350   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (83)
1 – 10 of 83
ILF2
Tbio
Novelty:  0.01598188
p_int:  0.996156471
p_ni:  0.003843529
Score:  0.575
Data Source:  BioPlex,STRINGDB
STAU1
Tbio
Novelty:  0.00565778
p_int:  0.964005348
p_ni:  0.035994652
Score:  0.786
Data Source:  BioPlex,STRINGDB
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.931842725
p_ni:  0.068157275
Score:  0.219
Data Source:  BioPlex,STRINGDB
MAGEB10
Tdark
Novelty:  2.96156972
p_int:  0.914445768
p_ni:  0.08555423
p_wrong:  1e-9
Score:  0.199
Data Source:  BioPlex,STRINGDB
RBM34
Tdark
Novelty:  0.58131282
p_int:  0.868809519
p_ni:  0.13119048
Score:  0.289
Data Source:  BioPlex,STRINGDB
WDR46
Tbio
Novelty:  0.19307408
p_int:  0.867466671
p_ni:  0.132533328
p_wrong:  1e-9
Data Source:  BioPlex
RASL10A
Tbio
Family:  Enzyme
Novelty:  0.1724649
p_int:  0.83047104
p_ni:  0.16952896
Score:  0.259
Data Source:  BioPlex,STRINGDB
RPL30
Tbio
Novelty:  0.0134194
p_int:  0.814462677
p_ni:  0.185536933
p_wrong:  3.9e-7
Data Source:  BioPlex
DGCR8
Tbio
Novelty:  0.00271221
p_int:  0.806221713
p_ni:  0.193778287
Score:  0.926
Data Source:  BioPlex,STRINGDB
STRBP
Tbio
Novelty:  0.00919158
p_int:  0.787720963
p_ni:  0.212279037
Score:  0.818
Data Source:  BioPlex,STRINGDB
Pathways (13)
Gene Silencing by RNA (R-HSA-211000)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene Silencing by RNA
Reactome
Gene expression (Transcription)
Reactome
MicroRNA (miRNA) biogenesis
Reactome
Small interfering RNA (siRNA) biogenesis
Name
Explore in Pharos
Explore in Source
Gene Silencing by RNA
Gene expression (Transcription)
MicroRNA (miRNA) biogenesis
Small interfering RNA (siRNA) biogenesis
Gene Ontology Terms (28)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1
0
1.1
76.7
aspartate aminotransferase measurement
1
1
0
8.1
65.6
heart function measurement
2
1
2
60.2
left ventricular diastolic function measurement
1
1
0
2
50.6
vital capacity
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
76.7
aspartate aminotransferase measurement
0
8.1
65.6
heart function measurement
2
60.2
left ventricular diastolic function measurement
0
2
50.6
vital capacity
1
47.7
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein activator of interferon induced protein kinase EIF2AK2
VGNC:6371
459776
Macaque
protein activator of interferon induced protein kinase EIF2AK2
703063
Mouse
MGI:1344375
23992
Rat
RGD:1306707
311130
Dog
protein activator of interferon induced protein kinase EIF2AK2
VGNC:44991
488423
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein activator of interferon induced protein kinase EIF2AK2
Macaque
protein activator of interferon induced protein kinase EIF2AK2
Mouse
Rat
Dog
protein activator of interferon induced protein kinase EIF2AK2
Publication Statistics
PubMed Score 54.09
PubMed score by year
PubTator Score 56.53
PubTator score by year
Patents
Patents by year