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Tdark
JRK
Jerky protein homolog

Protein Summary
Description
May bind DNA. This gene encodes a conserved protein that is similar to DNA-binding proteins, such as major centromere autoantigen B (CENPB). Inactivation of the related gene in mice resulted in epileptic seizures. Childhood Absence Epilepsy (CAE) has been mapped to the same chromosomal location (8q24.3) as this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000571961
  • ENSP00000461610
  • ENSG00000234616
  • ENST00000612905
  • ENSP00000482410
  • ENST00000614134
  • ENSP00000485390
  • ENST00000615982
  • ENSP00000483808

Symbol
  • JH8
  • JH8
  • jerky
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
0.95
transcription factor binding site profile
0.85
cell type or tissue
0.79
histone modification site profile
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.49   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.49   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
VWA5A
Tbio
Novelty:  0.0802354
p_int:  0.904205096
p_ni:  4.6e-8
p_wrong:  0.095794858
Score:  0.332
Data Source:  BioPlex,STRINGDB
FOXG1
Tbio
Family:  TF
Novelty:  0.00154897
Score:  0.644
Data Source:  STRINGDB
ME2
Tbio
Novelty:  0.03635548
Score:  0.64
Data Source:  STRINGDB
SGCE
Tbio
Novelty:  0.00449577
Score:  0.629
Data Source:  STRINGDB
FAM102B
Tdark
Novelty:  1.44024802
Score:  0.614
Data Source:  STRINGDB
RASAL3
Tbio
Novelty:  0.22098972
Score:  0.613
Data Source:  STRINGDB
TRAPPC5
Tdark
Novelty:  0.22558077
Score:  0.588
Data Source:  STRINGDB
CRLF1
Tbio
Novelty:  0.02127014
Score:  0.54
Data Source:  STRINGDB
FGF14
Tbio
Novelty:  0.01613466
Score:  0.539
Data Source:  STRINGDB
FRMD7
Tbio
Novelty:  0.01561885
Score:  0.539
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
1
1.3
92.4
pepsinogen I/II ratio
1
3
3
89.8
1
1
0
1.4
80.9
2
2
2
70.4
3
2
0
1.1
60.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.3
92.4
pepsinogen I/II ratio
3
89.8
0
1.4
80.9
2
70.4
0
1.1
60.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
Jrk helix-turn-helix protein
694627
Mouse
MGI:106214
16469
Rat
RGD:1306316
315073
Horse
Jrk helix-turn-helix protein
VGNC:19231
100066602
Species
Name
OMA
EggNOG
Inparanoid
Macaque
Jrk helix-turn-helix protein
Mouse
Rat
Horse
Jrk helix-turn-helix protein
Publication Statistics
PubMed Score 72.49
PubMed score by year
PubTator Score 6.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title