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Tbio
SKAP2
Src kinase-associated phosphoprotein 2

Protein Summary
Description
May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345317
  • ENSP00000005587
  • ENSG00000005020

Symbol
  • PRAP
  • RA70
  • SAPS
  • SCAP2
  • SKAP55R
  • PRAP
  • RA70
  • SAPS
  • SCAP2
  • SKAP55R
  • SKAP-HOM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.95
histone modification site profile
0.88
transcription factor binding site profile
0.87
virus perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.85   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.85   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
SKAP1
Tbio
Family:  Enzyme
Novelty:  0.03753848
p_int:  0.999998833
p_ni:  0.000001167
Score:  0.193
Data Source:  BioPlex,STRINGDB
RGS3
Tbio
Novelty:  0.01749541
p_int:  0.99999809
p_ni:  0.00000191
p_wrong:  1e-9
Score:  0.195
Data Source:  BioPlex,STRINGDB
ABHD5
Tbio
Family:  Enzyme
Novelty:  0.00806614
p_int:  0.999959669
p_ni:  0.000040326
p_wrong:  5e-9
Score:  0.221
Data Source:  BioPlex,STRINGDB
FRMD1
Tdark
Novelty:  0.96833141
p_int:  0.999941969
p_ni:  0.000058028
p_wrong:  2e-9
Data Source:  BioPlex
SNRPB
Tbio
Novelty:  0.01503535
p_int:  0.99953947
p_ni:  0.00046053
Data Source:  BioPlex
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.998983532
p_ni:  0.00008947
p_wrong:  0.000926998
Data Source:  BioPlex
FYB1
Tbio
Novelty:  0.00247573
Score:  0.977
Data Source:  Reactome,STRINGDB
FYN
Tclin
Family:  Kinase
Novelty:  0.00072167
Score:  0.92
Data Source:  STRINGDB
SIRPA
Tbio
Family:  Enzyme
Novelty:  0.0021102
Score:  0.907
Data Source:  Reactome,STRINGDB
CD47
Tchem
Novelty:  0.00129086
Score:  0.906
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Cell-Cell communication (R-HSA-1500931)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell-Cell communication
Reactome
Signal regulatory protein family interactions
Name
Explore in Pharos
Explore in Source
Cell-Cell communication
Signal regulatory protein family interactions
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
1
1
1
56.2
lymphocyte percentage of leukocytes
1
1
1
52.7
2
1
0
1.1
49.5
eosinophil count
1
1
1
47.7
1
1
0
1.1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
1
56.2
lymphocyte percentage of leukocytes
1
52.7
0
1.1
49.5
eosinophil count
1
47.7
0
1.1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
src kinase associated phosphoprotein 2
VGNC:4507
463306
Macaque
src kinase associated phosphoprotein 2
701461
Mouse
MGI:1889206
54353
Rat
RGD:620159
155183
Dog
src kinase associated phosphoprotein 2
VGNC:46197
482366
Species
Name
OMA
EggNOG
Inparanoid
Chimp
src kinase associated phosphoprotein 2
Macaque
src kinase associated phosphoprotein 2
Mouse
Rat
Dog
src kinase associated phosphoprotein 2
Publication Statistics
PubMed Score 177.85
PubMed score by year
PubTator Score 95.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title