Protein Summary
Adapter molecule functioning in neural development. May regulate SIAH1 activity. The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. [provided by RefSeq, Jan 2017]
- ENST00000371230
- ENSP00000360274
- ENSG00000173406
- ENST00000371231
- ENSP00000360275
- ENST00000371236
- ENSP00000360280
- ENST00000414851
- ENSP00000387581
- ENST00000420954
- ENSP00000395296
- SCA37
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 1 | ||
biological process | 0.91 | ||
hub protein | 0.88 | ||
phenotype | 0.85 | ||
kinase | 0.82 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.9 (req: < 5)
Gene RIFs: 33 (req: <= 3)
Antibodies: 489 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.9 (req: >= 5)
Gene RIFs: 33 (req: > 3)
Antibodies: 489 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (49)
Nearest Tclin Targets
Pathways (6)
Reactome (3)
PathwayCommons (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | Reelin signalling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
Reelin signalling pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (1)
Components (9)
Processes (18)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 1 | 3 | 3 | 83.5 | |||||
mathematical ability | 4 | 8 | 10 | 79.3 | |||||
insomnia measurement | 3 | 2 | 0 | 1 | 63 | ||||
1 | 1 | 0 | 1.3 | 61.4 | |||||
body mass index | 1 | 1 | 1 | 38.2 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 3 | 83.5 | |||||
mathematical ability | 10 | 79.3 | |||||
insomnia measurement | 0 | 1 | 63 | ||||
0 | 1.3 | 61.4 | |||||
body mass index | 1 | 38.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | DAB1, reelin adaptor protein | VGNC:12998 | 740508 | |||||
Macaque | DAB1, reelin adaptor protein | 716200 | ||||||
Mouse | MGI:108554 | 13131 | ||||||
Rat | RGD:628770 | 266729 | ||||||
Dog | DAB1, reelin adaptor protein | VGNC:39758 | 610344 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | DAB1, reelin adaptor protein | |||||
Macaque | DAB1, reelin adaptor protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | DAB1, reelin adaptor protein | |||||
Publication Statistics
PubMed Score 12.90
PubMed score by year
PubTator Score 84.31
PubTator score by year
Related Publications
Text Mined References (64)
GeneRif Annotations (33)
Items per page:
0 of 0
PMID | Year | Title |
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