Protein Classes
Protein Summary
Adapter molecule functioning in neural development. May regulate SIAH1 activity. The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. [provided by RefSeq, Jan 2017]
- ENST00000371230
- ENSP00000360274
- ENSG00000173406
- ENST00000371231
- ENSP00000360275
- ENST00000371236
- ENSP00000360280
- ENST00000414851
- ENSP00000387581
- ENST00000420954
- ENSP00000395296
- SCA37
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 1 | ||
biological process | 0.91 | ||
hub protein | 0.88 | ||
phenotype | 0.85 | ||
kinase | 0.82 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.36 (req: < 5)
Gene RIFs: 33 (req: <= 3)
Antibodies: 489 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.36 (req: >= 5)
Gene RIFs: 33 (req: > 3)
Antibodies: 489 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mathematical ability | 4 | 8 | 10 | 95 | |||||
self reported educational attainment | 1 | 3 | 3 | 94.6 | |||||
insomnia measurement | 3 | 2 | 0 | 1 | 79.1 | ||||
1 | 1 | 0 | 1.3 | 76.9 | |||||
body mass index | 1 | 1 | 1 | 61.2 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mathematical ability | 10 | 95 | |||||
self reported educational attainment | 3 | 94.6 | |||||
insomnia measurement | 0 | 1 | 79.1 | ||||
0 | 1.3 | 76.9 | |||||
body mass index | 1 | 61.2 | |||||
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | DAB1, reelin adaptor protein | VGNC:12998 | 740508 | |||||
Macaque | DAB1, reelin adaptor protein | 716200 | ||||||
Mouse | MGI:108554 | 13131 | ||||||
Rat | RGD:628770 | 266729 | ||||||
Dog | DAB1, reelin adaptor protein | VGNC:39758 | 610344 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | DAB1, reelin adaptor protein | |||||
Macaque | DAB1, reelin adaptor protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | DAB1, reelin adaptor protein | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (6)
Reactome (3)
PathwayCommons (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | Reelin signalling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
Reelin signalling pathway | ||||
Gene Ontology Terms (28)
Functions (1)
Components (9)
Processes (18)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (49)
1 – 10 of 49
VLDLR
Novelty: 0.00352547
Score: 0.989
Data Source: Reactome,STRINGDB
RELN
Novelty: 0.005326
Score: 0.988
Data Source: Reactome,STRINGDB
LRP8
Novelty: 0.00473606
Score: 0.985
Data Source: STRINGDB
PAFAH1B1
Family: Enzyme
Novelty: 0.00256206
Score: 0.976
Data Source: STRINGDB
FYN
Family: Kinase
Novelty: 0.00072167
Score: 0.965
Data Source: Reactome,STRINGDB
CRKL
Novelty: 0.0051181
Score: 0.961
Data Source: STRINGDB
SH3KBP1
Family: Enzyme
Novelty: 0.01454593
Score: 0.947
Data Source: Reactome,STRINGDB
RAPGEF1
Novelty: 0.00365765
Score: 0.932
Data Source: STRINGDB
AKT1
Family: Kinase
Novelty: 0.00003185
Score: 0.921
Data Source: STRINGDB
GRIN2A
Family: IC
Novelty: 0.00060035
Score: 0.92
Data Source: STRINGDB
Publication Statistics
PubMed Score 12.36
PubMed score by year
PubTator Score 84.31
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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GWAS Trait