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Tbio
DAB1
Disabled homolog 1

Protein Classes
Protein Summary
Description
Adapter molecule functioning in neural development. May regulate SIAH1 activity. The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371230
  • ENSP00000360274
  • ENSG00000173406
  • ENST00000371231
  • ENSP00000360275
  • ENST00000371236
  • ENSP00000360280
  • ENST00000414851
  • ENSP00000387581
  • ENST00000420954
  • ENSP00000395296

Symbol
  • SCA37
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
biological process
0.91
hub protein
0.88
phenotype
0.85
kinase
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.36   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 489   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.36   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 489   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
8
10
95
self reported educational attainment
1
3
3
94.6
insomnia measurement
3
2
0
1
79.1
1
1
0
1.3
76.9
body mass index
1
1
1
61.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
10
95
self reported educational attainment
3
94.6
insomnia measurement
0
1
79.1
0
1.3
76.9
body mass index
1
61.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DAB1, reelin adaptor protein
VGNC:12998
740508
Macaque
DAB1, reelin adaptor protein
716200
Mouse
MGI:108554
13131
Rat
RGD:628770
266729
Dog
DAB1, reelin adaptor protein
VGNC:39758
610344
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DAB1, reelin adaptor protein
Macaque
DAB1, reelin adaptor protein
Mouse
Rat
Dog
DAB1, reelin adaptor protein
Pathways (6)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Reelin signalling pathway
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Reelin signalling pathway
Gene Ontology Terms (28)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (49)
1 – 10 of 49
VLDLR
Tbio
Novelty: 0.00352547
Score: 0.989
Data Source: Reactome,STRINGDB
RELN
Tbio
Novelty: 0.005326
Score: 0.988
Data Source: Reactome,STRINGDB
LRP8
Tbio
Novelty: 0.00473606
Score: 0.985
Data Source: STRINGDB
PAFAH1B1
Tbio
Family: Enzyme
Novelty: 0.00256206
Score: 0.976
Data Source: STRINGDB
FYN
Tclin
Family: Kinase
Novelty: 0.00072167
Score: 0.965
Data Source: Reactome,STRINGDB
CRKL
Tbio
Novelty: 0.0051181
Score: 0.961
Data Source: STRINGDB
SH3KBP1
Tbio
Family: Enzyme
Novelty: 0.01454593
Score: 0.947
Data Source: Reactome,STRINGDB
RAPGEF1
Tbio
Novelty: 0.00365765
Score: 0.932
Data Source: STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.921
Data Source: STRINGDB
GRIN2A
Tclin
Family: IC
Novelty: 0.00060035
Score: 0.92
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.36

PubMed score by year
PubTator Score  84.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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