Tbio CSDE1 Cold shock domain-containing protein E1

Protein Summary

Description

RNA-binding protein. Required for internal initiation of translation of human rhinovirus RNA. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.

Uniprot Accession IDs

• O75534
• A8K281
• E9PGZ0
• G5E9Q2
• O94961
• Q5TF04
• Q5TF05
• Q68DF1
• Q68DI9
• Q9Y2S4

Gene Name

• CSDE1

Ensembl ID

• ENST00000261443
• ENSP00000261443
• ENSG00000009307
• ENST00000339438
• ENSP00000342408
• ENST00000358528
• ENSP00000351329
• ENST00000369530
• ENSP00000358543
• ENST00000438362
• ENSP00000407724
• ENST00000534699
• ENSP00000432958
• ENST00000610726
• ENSP00000481762

Symbol

• D1S155E
• KIAA0885
• NRU
• UNR
• UNR
• D1S155E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	0.97
transcription factor binding site profile	0.95
virus perturbation	0.92
kinase perturbation	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.21   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 188   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.21   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0