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Tbio
CSDE1
Cold shock domain-containing protein E1

Protein Summary
Description
RNA-binding protein. Required for internal initiation of translation of human rhinovirus RNA. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261443
  • ENSP00000261443
  • ENSG00000009307
  • ENST00000339438
  • ENSP00000342408
  • ENST00000358528
  • ENSP00000351329
  • ENST00000369530
  • ENSP00000358543
  • ENST00000438362
  • ENSP00000407724
  • ENST00000534699
  • ENSP00000432958
  • ENST00000610726
  • ENSP00000481762

Symbol
  • D1S155E
  • KIAA0885
  • NRU
  • UNR
  • UNR
  • D1S155E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
0.97
transcription factor binding site profile
0.95
virus perturbation
0.92
kinase perturbation
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.82   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.82   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (91)
STRAP
Tbio
Family:  Enzyme
Novelty:  0.0336013
p_int:  0.999999499
p_ni:  5.01e-7
Score:  0.966
Data Source:  BioPlex,STRINGDB
FAM19A3
Tdark
Novelty:  0.37183557
p_int:  0.978418321
p_ni:  0.021581679
Data Source:  BioPlex
SAMD4A
Tbio
Novelty:  0.04440962
p_int:  0.923271907
p_ni:  0.076728093
Score:  0.228
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.754470084
p_ni:  0.245529916
Score:  0.26
Data Source:  BioPlex,STRINGDB
SYNCRIP
Tbio
Novelty:  0.01479381
Score:  0.97
Data Source:  STRINGDB
YBX1
Tbio
Family:  TF
Novelty:  0.00132108
Score:  0.941
Data Source:  STRINGDB
DHX9
Tbio
Family:  Enzyme
Novelty:  0.00130907
Score:  0.937
Data Source:  STRINGDB
IGF2BP1
Tbio
Novelty:  0.00830935
Score:  0.926
Data Source:  STRINGDB
HNRNPU
Tbio
Novelty:  0.00517939
Score:  0.909
Data Source:  STRINGDB
PABPC1
Tbio
Novelty:  0.00197523
Score:  0.871
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
37.6
comparative body size at age 10, self-reported
1
1
1
21.5
age at first sexual intercourse measurement
1
1
1
2.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
37.6
comparative body size at age 10, self-reported
1
21.5
age at first sexual intercourse measurement
1
2.9
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cold shock domain containing E1
VGNC:8247
457145
Macaque
cold shock domain containing E1
708897
Mouse
MGI:92356
229663
Rat
RGD:619726
117180
Dog
cold shock domain containing E1
VGNC:39650
475807
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cold shock domain containing E1
Macaque
cold shock domain containing E1
Mouse
Rat
Dog
cold shock domain containing E1
Publication Statistics
PubMed Score 53.82
PubMed score by year
PubTator Score 33.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title