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Tbio
BANF1
Barrier-to-autointegration factor

Protein Summary
Description
Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non-specific dsDNA-binding sites which may promote DNA cross-bridging. (Microbial infection) Exploited by retroviruses for inhibiting self-destructing autointegration of retroviral DNA, thereby promoting integration of viral DNA into the host chromosome. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. (Microbial infection) In case of poxvirus infection, has an antiviral activity by blocking viral DNA replication. The protein encoded by this gene was first identified by its ability to protect retroviruses from intramolecular integration and therefore promote i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312175
  • ENSP00000310275
  • ENSG00000175334
  • ENST00000445560
  • ENSP00000416128
  • ENST00000527348
  • ENSP00000432867
  • ENST00000533166
  • ENSP00000433760

Symbol
  • BAF
  • BCRG1
  • BAF
  • NGPS
  • BCRP1
  • D14S1460
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
transcription factor perturbation
0.98
histone modification site profile
0.92
disease perturbation
0.9
virus perturbation
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1098.36   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1098.36   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (147)
EMD
Tbio
Novelty:  0.00135202
Score:  0.998
Data Source:  Reactome,STRINGDB
VRK1
Tbio
Family:  Kinase
Novelty:  0.00761136
Score:  0.998
Data Source:  Reactome,STRINGDB
LEMD3
Tbio
Novelty:  0.00579701
Score:  0.995
Data Source:  STRINGDB
ANKLE2
Tbio
Novelty:  0.0995907
Score:  0.986
Data Source:  STRINGDB
LMNB1
Tbio
Novelty:  0.00127348
Score:  0.981
Data Source:  STRINGDB
LEMD2
Tbio
Novelty:  0.12460123
Score:  0.957
Data Source:  STRINGDB
ACTL6A
Tbio
Novelty:  0.01892162
Score:  0.935
Data Source:  STRINGDB
PPP2R1A
Tbio
Family:  Enzyme
Novelty:  0.01134139
Score:  0.907
Data Source:  Reactome,STRINGDB
PPP2CA
Tchem
Family:  Enzyme
Novelty:  0.00496839
Score:  0.901
Data Source:  Reactome,STRINGDB
PPP2R2A
Tchem
Family:  Enzyme
Novelty:  0.01723628
Score:  0.901
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (36)
2-LTR circle formation (R-HSA-164843)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
2-LTR circle formation
Reactome
APOBEC3G mediated resistance to HIV-1 infection
Reactome
Autointegration results in viral DNA circles
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
2-LTR circle formation
APOBEC3G mediated resistance to HIV-1 infection
Autointegration results in viral DNA circles
Cell Cycle
Cell Cycle, Mitotic
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
2
2
2
89.6
C-reactive protein measurement
2
2
2
70.4
BMI-adjusted waist circumference
1
2
2
67.9
urate measurement
1
2
2
57.8
body fat distribution
2
1
2
51.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
2
89.6
C-reactive protein measurement
2
70.4
BMI-adjusted waist circumference
2
67.9
urate measurement
2
57.8
body fat distribution
2
51.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
barrier to autointegration factor 1
VGNC:10581
746065
Macaque
barrier to autointegration factor 1
715124
Mouse
MGI:1346330
23825
Rat
RGD:620662
114087
Dog
barrier to autointegration factor 1
VGNC:51841
611961
Species
Name
OMA
EggNOG
Inparanoid
Chimp
barrier to autointegration factor 1
Macaque
barrier to autointegration factor 1
Mouse
Rat
Dog
barrier to autointegration factor 1
Publication Statistics
PubMed Score 1098.36
PubMed score by year
PubTator Score 332.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title