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Tbio
BANF1
Barrier-to-autointegration factor

Protein Summary
Description
Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non-specific dsDNA-binding sites which may promote DNA cross-bridging. (Microbial infection) Exploited by retroviruses for inhibiting self-destructing autointegration of retroviral DNA, thereby promoting integration of viral DNA into the host chromosome. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. (Microbial infection) In case of poxvirus infection, has an antiviral activity by blocking viral DNA replication. The protein encoded by this gene was first identified by its ability to protect retroviruses from intramolecular integration and therefore promote i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312175
  • ENSP00000310275
  • ENSG00000175334
  • ENST00000445560
  • ENSP00000416128
  • ENST00000527348
  • ENSP00000432867
  • ENST00000533166
  • ENSP00000433760

Symbol
  • BAF
  • BCRG1
  • BAF
  • NGPS
  • BCRP1
  • D14S1460
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
transcription factor perturbation
0.98
histone modification site profile
0.92
disease perturbation
0.9
virus perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1052.08   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1052.08   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (36)
2-LTR circle formation (R-HSA-164843)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
2-LTR circle formation
Reactome
APOBEC3G mediated resistance to HIV-1 infection
Reactome
Autointegration results in viral DNA circles
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
2-LTR circle formation
APOBEC3G mediated resistance to HIV-1 infection
Autointegration results in viral DNA circles
Cell Cycle
Cell Cycle, Mitotic
Gene Ontology Terms (19)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (147)
1 – 10 of 147
EMD
Tbio
Novelty: 0.00135202
Score: 0.998
Data Source: Reactome,STRINGDB
VRK1
Tbio
Family: Kinase
Novelty: 0.00761136
Score: 0.998
Data Source: Reactome,STRINGDB
LEMD3
Tbio
Novelty: 0.00579701
Score: 0.995
Data Source: STRINGDB
ANKLE2
Tbio
Novelty: 0.0995907
Score: 0.986
Data Source: STRINGDB
LMNB1
Tbio
Novelty: 0.00127348
Score: 0.981
Data Source: STRINGDB
LEMD2
Tbio
Novelty: 0.12460123
Score: 0.957
Data Source: STRINGDB
ACTL6A
Tbio
Novelty: 0.01892162
Score: 0.935
Data Source: STRINGDB
PPP2R1A
Tbio
Family: Enzyme
Novelty: 0.01134139
Score: 0.907
Data Source: Reactome,STRINGDB
PPP2CA
Tchem
Family: Enzyme
Novelty: 0.00496839
Score: 0.901
Data Source: Reactome,STRINGDB
PPP2R2A
Tchem
Family: Enzyme
Novelty: 0.01723628
Score: 0.901
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1052.08

PubMed score by year
PubTator Score  332.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer