Protein Summary
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7 ...more
- ENST00000263360
- ENSP00000263360
- ENSG00000074266
- ENST00000327320
- ENSP00000315587
- ENST00000351625
- ENSP00000338186
- HEED
- COGIS
- WAIT1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor binding site profile | 0.9 | ||
kinase perturbation | 0.84 | ||
biological process | 0.8 | ||
transcription factor | 0.8 | ||
virus perturbation | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 150.58 (req: < 5)
Gene RIFs: 25 (req: <= 3)
Antibodies: 348 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 150.58 (req: >= 5)
Gene RIFs: 25 (req: > 3)
Antibodies: 348 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 158
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (158)
Protein-Protein Interactions (218)
SUZ12
Novelty: 0.00402353
p_int: 0.999999948
p_ni: 5.2e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
EZH2
Family: Epigenetic
Novelty: 0.00052816
p_int: 0.999999645
p_ni: 3.55e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
AEBP2
Novelty: 0.05974483
p_int: 0.999998836
p_ni: 0.000001164
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
RBBP7
Novelty: 0.01795364
p_int: 0.999995161
p_ni: 0.000004839
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
PHF19
Family: Epigenetic
Novelty: 0.02289037
p_int: 0.999991034
p_ni: 0.000008966
Score: 0.981
Data Source: BioPlex,Reactome,STRINGDB
INTU
Novelty: 0.02714388
p_int: 0.99645493
p_ni: 0.003545065
p_wrong: 5e-9
Score: 0.734
Data Source: BioPlex,STRINGDB
BTRC
Novelty: 0.00293475
p_int: 0.993126098
p_ni: 0.006873901
p_wrong: 2e-9
Score: 0.545
Data Source: BioPlex,STRINGDB
FBXW11
Novelty: 0.0715377
p_int: 0.915091602
p_ni: 0.084907047
p_wrong: 0.000001351
Score: 0.207
Data Source: BioPlex,STRINGDB
CLASRP
Novelty: 0.00582947
p_int: 0.759366979
p_ni: 0.231223556
p_wrong: 0.009409465
Score: 0.179
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (27)
Reactome (21)
PathwayCommons (1)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of HOX genes during differentiation | ||||
Reactome | Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Reactome | Cellular Senescence | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of HOX genes during differentiation | ||||
Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Cellular Senescence | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (4)
Components (6)
Processes (11)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
8 | 2 | 0 | 1.2 | 82.6 | |||||
family history of Alzheimer’s disease | 3 | 2 | 0 | 1.1 | 82.6 | ||||
smoking status measurement | 2 | 1 | 2 | 63.1 | |||||
smoking initiation | 2 | 2 | 2 | 39.6 | |||||
red blood cell distribution width | 1 | 1 | 1 | 12.8 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.2 | 82.6 | |||||
family history of Alzheimer’s disease | 0 | 1.1 | 82.6 | ||||
smoking status measurement | 2 | 63.1 | |||||
smoking initiation | 2 | 39.6 | |||||
red blood cell distribution width | 1 | 12.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | embryonic ectoderm development | 703866 | ||||||
Mouse | MGI:95286 | 13626 | ||||||
Rat | RGD:1309782 | 293104 | ||||||
Dog | embryonic ectoderm development | VGNC:40206 | 476779 | |||||
Horse | embryonic ectoderm development | VGNC:17428 | 100061139 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | embryonic ectoderm development | |||||
Mouse | ||||||
Rat | ||||||
Dog | embryonic ectoderm development | |||||
Horse | embryonic ectoderm development | |||||
Publication Statistics
PubMed Score 150.58
PubMed score by year
PubTator Score 125.88
PubTator score by year
Related Publications
Text Mined References (60)
GeneRif Annotations (25)
Items per page:
0 of 0
PMID | Year | Title |
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