Tchem EED Polycomb protein EED

Protein Summary

Description

Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75530
• A8K7V5
• O00149
• Q6NTH2
• Q7LDA5
• Q7LDG8
• Q86VV2
• Q9UNY7
• hEED

Gene Name

• EED

Ensembl ID

• ENST00000263360
• ENSP00000263360
• ENSG00000074266
• ENST00000327320
• ENSP00000315587
• ENST00000351625
• ENSP00000338186

Symbol

• HEED
• COGIS
• WAIT1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.9
kinase perturbation	0.84
biological process	0.8
transcription factor	0.8
virus perturbation	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.58   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 348   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.58   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 348   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 158

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (1)

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1 – 1 of 1

tazemetostat

EEDTchem

INHIBITOR pIC50 : 6.41

Active Ligands (158)

Explore Active Ligands

1 – 10 of 158

A-395

EEDTchem

pKd : 8.7

CHEMBL4637520

EEDTchem

pIC50 : 9.7

CHEMBL4637096

EEDTchem

pIC50 : 9.7

CHEMBL4060827

EEDTchem

pKd : 8.4

CHEMBL4093096

EEDTchem

pKi : 9.52

CHEMBL4084398

EEDTchem

pKd : 8

CHEMBL4638412

EEDTchem

pIC50 : 9.52

CHEMBL4645324

EEDTchem

pIC50 : 9.4

CHEMBL4643880

EEDTchem

pIC50 : 9.4

CHEMBL4645310

EEDTchem

pIC50 : 9.4

Protein-Protein Interactions (218)

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1 – 10 of 218

• See Interactions on String-DB

SUZ12

Tbio

Novelty:  0.00402353

p_int:  0.999999948

p_ni:  5.2e-8

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

EZH2

Tclin

Family:  Epigenetic

Novelty:  0.00052816

p_int:  0.999999645

p_ni:  3.55e-7

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

AEBP2

Tbio

Novelty:  0.05974483

p_int:  0.999998836

p_ni:  0.000001164

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

RBBP7

Tbio

Novelty:  0.01795364

p_int:  0.999995161

p_ni:  0.000004839

Score:  0.997

Data Source:  BioPlex,Reactome,STRINGDB

PHF19

Tbio

Family:  Epigenetic

Novelty:  0.02289037

p_int:  0.999991034

p_ni:  0.000008966

Score:  0.981

Data Source:  BioPlex,Reactome,STRINGDB

INTU

Tbio

Novelty:  0.02714388

p_int:  0.99645493

p_ni:  0.003545065

p_wrong:  5e-9

Score:  0.734

Data Source:  BioPlex,STRINGDB

BTRC

Tbio

Novelty:  0.00293475

p_int:  0.993126098

p_ni:  0.006873901

p_wrong:  2e-9

Score:  0.545

Data Source:  BioPlex,STRINGDB

FBXW11

Tbio

Novelty:  0.0715377

p_int:  0.915091602

p_ni:  0.084907047

p_wrong:  0.000001351

Score:  0.207

Data Source:  BioPlex,STRINGDB

CLASRP

Tbio

Novelty:  0.00582947

p_int:  0.759366979

p_ni:  0.231223556

p_wrong:  0.009409465

Score:  0.179

Data Source:  BioPlex,STRINGDB

RBBP4

Tbio

Novelty:  0.01062843

Score:  0.999

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (27)

Reactome (21)

PathwayCommons (1)

WikiPathways (5)

Activation of HOX genes during differentiation (R-HSA-5619507)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of HOX genes during differentiation	90 targets	R-HSA-5619507
Reactome	Activation of anterior HOX genes in hindbrain development during early embryogenesis	90 targets	R-HSA-5617472
Reactome	Cellular Senescence	164 targets	R-HSA-2559583
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897
Reactome	Cellular responses to stress	392 targets	R-HSA-2262752

Name	Explore in Pharos	Explore in Source
Activation of HOX genes during differentiation	90 targets	R-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesis	90 targets	R-HSA-5617472
Cellular Senescence	164 targets	R-HSA-2559583
Cellular responses to external stimuli	487 targets	R-HSA-8953897
Cellular responses to stress	392 targets	R-HSA-2262752

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (21)

Functions (4)

Components (6)

Processes (11)

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1 – 4 of 4

GO Term	Evidence	Assigned by
histone methyltransferase activity	Inferred from Direct Assay (IDA)	MGI
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
chromatin binding	Inferred from Electronic Annotation (IEA)	Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (7)

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1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Alzheimer's disease	EFO_0000249	8	2	0	1.2	82.6
family history of Alzheimer’s disease	EFO_0009268	3	2	0	1.1	82.6
smoking status measurement	EFO_0006527	2	1	2		63.1
smoking initiation	EFO_0005670	2	2	2		39.6
red blood cell distribution width	EFO_0005192	1	1	1		12.8

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Alzheimer's disease	EFO_0000249	0	1.2	82.6
family history of Alzheimer’s disease	EFO_0009268	0	1.1	82.6
smoking status measurement	EFO_0006527	2		63.1
smoking initiation	EFO_0005670	2		39.6
red blood cell distribution width	EFO_0005192	1		12.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative initiation
Alternative splicing
Chromatin regulator
Chromosome
Complete proteome
Disease mutation
Methylation
Nucleus

GWAS Trait Find Similar Targets

No Header	No Header
Alzheimer's disease
family history of Alzheimer’s disease
mathematical ability
red blood cell distribution width
smoking behavior
smoking initiation
smoking status measurement

MGI Phenotype Find Similar Targets

No Header	No Header
growth/size/body region phenotype
integument phenotype
pigmentation phenotype

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	embryonic ectoderm development		703866
Mouse	embryonic ectoderm development	MGI:95286	13626
Rat	embryonic ectoderm development	RGD:1309782	293104
Dog	embryonic ectoderm development	VGNC:40206	476779
Horse	embryonic ectoderm development	VGNC:17428	100061139

Species	Name	OMA	EggNOG	Inparanoid
Macaque	embryonic ectoderm development
Mouse	embryonic ectoderm development
Rat	embryonic ectoderm development
Dog	embryonic ectoderm development
Horse	embryonic ectoderm development

Publication Statistics

PubMed Score 150.58

PubMed score by year

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PubTator Score 125.88

PubTator score by year

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Related Publications

Text Mined References (60)

GeneRif Annotations (25)

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PMID	Year	Title