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Tchem
EED
Polycomb protein EED

Protein Summary
Description
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263360
  • ENSP00000263360
  • ENSG00000074266
  • ENST00000327320
  • ENSP00000315587
  • ENST00000351625
  • ENSP00000338186

Symbol
  • HEED
  • COGIS
  • WAIT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
kinase perturbation
0.84
biological process
0.8
transcription factor
0.8
virus perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.98   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 348   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.98   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 348   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
A-395
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
1
2
87.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
87.8
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
embryonic ectoderm development
703866
Mouse
MGI:95286
13626
Rat
RGD:1309782
293104
Dog
embryonic ectoderm development
VGNC:40206
476779
Horse
embryonic ectoderm development
VGNC:17428
100061139
Species
Name
OMA
EggNOG
Inparanoid
Macaque
embryonic ectoderm development
Mouse
Rat
Dog
embryonic ectoderm development
Horse
embryonic ectoderm development
Protein Structure (41 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75530-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 41
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Protein-Protein Interactions (218)
1 – 10 of 218
SUZ12
Tbio
Novelty: 0.00402353
p_int: 0.999999948
p_ni: 5.2e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
EZH2
Tclin
Family: Epigenetic
Novelty: 0.00052816
p_int: 0.999999645
p_ni: 3.55e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
AEBP2
Tbio
Novelty: 0.05974483
p_int: 0.999998836
p_ni: 0.000001164
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
RBBP7
Tbio
Novelty: 0.01795364
p_int: 0.999995161
p_ni: 0.000004839
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
PHF19
Tbio
Family: Epigenetic
Novelty: 0.02289037
p_int: 0.999991034
p_ni: 0.000008966
Score: 0.981
Data Source: BioPlex,Reactome,STRINGDB
INTU
Tbio
Novelty: 0.02714388
p_int: 0.99645493
p_ni: 0.003545065
p_wrong: 5e-9
Score: 0.734
Data Source: BioPlex,STRINGDB
BTRC
Tbio
Novelty: 0.00293475
p_int: 0.993126098
p_ni: 0.006873901
p_wrong: 2e-9
Score: 0.545
Data Source: BioPlex,STRINGDB
FBXW11
Tbio
Novelty: 0.0715377
p_int: 0.915091602
p_ni: 0.084907047
p_wrong: 0.000001351
Score: 0.207
Data Source: BioPlex,STRINGDB
CLASRP
Tbio
Novelty: 0.00582947
p_int: 0.759366979
p_ni: 0.231223556
p_wrong: 0.009409465
Score: 0.179
Data Source: BioPlex,STRINGDB
RBBP4
Tbio
Novelty: 0.01062843
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  143.98

PubMed score by year
PubTator Score  125.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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