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Tbio
KHDRBS3
KH domain-containing, RNA-binding, signal transduction-associated protein 3

Protein Classes
Protein Summary
Description
RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:10564820, PubMed:19561594, PubMed:26758068). Involved in splice site selection of vascular endothelial growth factor (PubMed:15901763). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members (PubMed:26758068). Targeted, cell-type specific splicing regulation of NRXN1 at ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355849
  • ENSP00000348108
  • ENSG00000131773

Symbol
  • SALP
  • SLM2
  • Etle
  • SALP
  • SLM2
  • SLM-2
  • TSTAR
  • T-STAR
  • etoile
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
kinase perturbation
0.88
transcription factor perturbation
0.8
PubMedID
0.72
transcription factor binding site profile
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
PTK6 Regulates Proteins Involved in RNA Processing (R-HSA-8849468)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
PTK6 Regulates Proteins Involved in RNA Processing
Reactome
Signal Transduction
Reactome
Signaling by Non-Receptor Tyrosine Kinases
Reactome
Signaling by PTK6
Name
Explore in Pharos
Explore in Source
PTK6 Regulates Proteins Involved in RNA Processing
Signal Transduction
Signaling by Non-Receptor Tyrosine Kinases
Signaling by PTK6
Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (81)
1 – 10 of 81
KHDRBS2
Tbio
Novelty: 0.01986638
p_int: 0.999999987
p_ni: 3e-9
p_wrong: 1.1e-8
Score: 0.792
Data Source: BioPlex,STRINGDB
RARRES1
Tbio
Family: Enzyme
Novelty: 0.04701793
p_int: 0.999994793
p_ni: 0.000005203
p_wrong: 4e-9
Data Source: BioPlex
PTK6
Tchem
Family: Kinase
Novelty: 0.00480214
Score: 0.964
Data Source: Reactome,STRINGDB
RBMX
Tbio
Novelty: 0.01705784
Score: 0.855
Data Source: STRINGDB
U2AF2
Tbio
Novelty: 0.00590935
Score: 0.834
Data Source: STRINGDB
PTBP2
Tbio
Novelty: 0.00879312
Score: 0.83
Data Source: STRINGDB
RBM3
Tbio
Novelty: 0.01066923
Score: 0.783
Data Source: STRINGDB
PRMT1
Tchem
Family: Epigenetic
Novelty: 0.0032916
Score: 0.716
Data Source: STRINGDB
KHDRBS1
Tbio
Novelty: 0.00647929
Score: 0.716
Data Source: STRINGDB
SIAH1
Tbio
Family: Enzyme
Novelty: 0.00831224
Score: 0.704
Data Source: STRINGDB
Publication Statistics
PubMed Score  211.00

PubMed score by year
PubTator Score  593.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer