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Tbio
KHDRBS3
KH domain-containing, RNA-binding, signal transduction-associated protein 3

Protein Classes
Protein Summary
Description
RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:10564820, PubMed:19561594, PubMed:26758068). Involved in splice site selection of vascular endothelial growth factor (PubMed:15901763). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members (PubMed:26758068). Targeted, cell-type specific splicing regulation of NRXN1 at ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355849
  • ENSP00000348108
  • ENSG00000131773

Symbol
  • SALP
  • SLM2
  • Etle
  • SALP
  • SLM2
  • SLM-2
  • TSTAR
  • T-STAR
  • etoile
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
kinase perturbation
0.88
transcription factor perturbation
0.8
PubMedID
0.72
transcription factor binding site profile
0.72


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.77   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.77   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
KH RNA binding domain containing, signal transduction associated 3
VGNC:10490
464413
Mouse
MGI:1313312
13992
Rat
RGD:620921
64015
Dog
KH RNA binding domain containing, signal transduction associated 3
VGNC:42337
475106
Horse
KH RNA binding domain containing, signal transduction associated 3
VGNC:19350
100058116
Species
Name
OMA
EggNOG
Inparanoid
Chimp
KH RNA binding domain containing, signal transduction associated 3
Mouse
Rat
Dog
KH RNA binding domain containing, signal transduction associated 3
Horse
KH RNA binding domain containing, signal transduction associated 3
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75525-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
PTK6 Regulates Proteins Involved in RNA Processing (R-HSA-8849468)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
PTK6 Regulates Proteins Involved in RNA Processing
Reactome
Signal Transduction
Reactome
Signaling by Non-Receptor Tyrosine Kinases
Reactome
Signaling by PTK6
Name
Explore in Pharos
Explore in Source
PTK6 Regulates Proteins Involved in RNA Processing
Signal Transduction
Signaling by Non-Receptor Tyrosine Kinases
Signaling by PTK6
Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (81)
1 – 10 of 81
KHDRBS2
Tbio
Novelty:  0.01986638
p_int:  0.999999987
p_ni:  3e-9
p_wrong:  1.1e-8
Score:  0.792
Data Source:  BioPlex,STRINGDB
RARRES1
Tbio
Family:  Enzyme
Novelty:  0.04701793
p_int:  0.999994793
p_ni:  0.000005203
p_wrong:  4e-9
Data Source:  BioPlex
PTK6
Tchem
Family:  Kinase
Novelty:  0.00480214
Score:  0.964
Data Source:  Reactome,STRINGDB
RBMX
Tbio
Novelty:  0.01705784
Score:  0.855
Data Source:  STRINGDB
U2AF2
Tbio
Novelty:  0.00590935
Score:  0.834
Data Source:  STRINGDB
PTBP2
Tbio
Novelty:  0.00879312
Score:  0.83
Data Source:  STRINGDB
RBM3
Tbio
Novelty:  0.01066923
Score:  0.783
Data Source:  STRINGDB
PRMT1
Tchem
Family:  Epigenetic
Novelty:  0.0032916
Score:  0.716
Data Source:  STRINGDB
KHDRBS1
Tbio
Novelty:  0.00647929
Score:  0.716
Data Source:  STRINGDB
SIAH1
Tbio
Family:  Enzyme
Novelty:  0.00831224
Score:  0.704
Data Source:  STRINGDB
Publication Statistics
PubMed Score  215.77

PubMed score by year
PubTator Score  593.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer