ECI2
Enoyl-CoA delta isomerase 2, mitochondrial
Protein Summary
Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity). This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2011]
- ENST00000380118
- ENSP00000369461
- ENSG00000198721
- DRS1
- HCA88
- PECI
- DRS1
- PECI
- ACBD2
- DRS-1
- HCA88
- dJ1013A10.3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.89 | ||
transcription factor perturbation | 0.8 | ||
disease perturbation | 0.79 | ||
protein domain | 0.73 | ||
virus perturbation | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 85.45 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 260 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 85.45 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 260 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0