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Tbio
ECI2
Enoyl-CoA delta isomerase 2, mitochondrial

Protein Summary
Description
Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity). This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380118
  • ENSP00000369461
  • ENSG00000198721

Symbol
  • DRS1
  • HCA88
  • PECI
  • DRS1
  • PECI
  • ACBD2
  • DRS-1
  • HCA88
  • dJ1013A10.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
transcription factor perturbation
0.8
disease perturbation
0.79
protein domain
0.73
virus perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.85   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 260   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.85   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (149)
ECH1
Tbio
Family:  Enzyme
Novelty:  0.02471875
p_int:  0.999999993
p_ni:  7e-9
Score:  0.854
Data Source:  BioPlex,STRINGDB
FBXL5
Tbio
Novelty:  0.03103624
p_int:  0.997712257
p_ni:  0.002287743
Data Source:  BioPlex
KANSL1
Tbio
Novelty:  0.03032662
p_int:  0.992135315
p_ni:  0.007864685
Score:  0.795
Data Source:  BioPlex,STRINGDB
TRAF1
Tbio
Novelty:  0.00526776
p_int:  0.973483134
p_ni:  0.026516866
Score:  0.322
Data Source:  BioPlex,STRINGDB
DBNL
Tbio
Novelty:  0.03390948
p_int:  0.960752838
p_ni:  0.039247162
Score:  0.236
Data Source:  BioPlex,STRINGDB
MAP7D2
Tdark
Novelty:  0.70744439
p_int:  0.95070394
p_ni:  0.049296059
p_wrong:  2e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
PDZK1P1
Tdark
p_int:  0.942044111
p_ni:  0.057952948
p_wrong:  0.000002941
Data Source:  BioPlex
PRIMPOL
Tbio
Family:  Enzyme
Novelty:  0.01285041
p_int:  0.914430412
p_ni:  0.085569588
Score:  0.239
Data Source:  BioPlex,STRINGDB
PDGFD
Tbio
Novelty:  0.00799996
p_int:  0.893684728
p_ni:  0.1063152
p_wrong:  7.2e-8
Score:  0.181
Data Source:  BioPlex,STRINGDB
CARTPT
Tbio
Novelty:  0.00224864
p_int:  0.88460644
p_ni:  0.115365163
p_wrong:  0.000028397
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Beta-oxidation of very long chain fatty acids (R-HSA-390247)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-oxidation of very long chain fatty acids
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Peroxisomal lipid metabolism
Name
Explore in Pharos
Explore in Source
Beta-oxidation of very long chain fatty acids
Fatty acid metabolism
Metabolism
Metabolism of lipids
Peroxisomal lipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
1
1
82
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
82
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
enoyl-CoA delta isomerase 2
VGNC:2776
471843
Macaque
enoyl-CoA delta isomerase 2
709579
Mouse
MGI:1346064
23986
Rat
Dog
enoyl-CoA delta isomerase 2
VGNC:40186
478706
Species
Name
OMA
EggNOG
Inparanoid
Chimp
enoyl-CoA delta isomerase 2
Macaque
enoyl-CoA delta isomerase 2
Mouse
Rat
Dog
enoyl-CoA delta isomerase 2
Publication Statistics
PubMed Score 43.85
PubMed score by year
PubTator Score 21.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title