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Tbio
HSBP1
Heat shock factor-binding protein 1

Protein Summary
Description
Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process. The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000433866
  • ENSP00000392896
  • ENSG00000230989
  • ENST00000570259
  • ENSP00000458007

Symbol
  • HSF1BP
  • NPC-A-13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
virus perturbation
0.99
disease perturbation
0.96
transcription factor perturbation
0.94
gene perturbation
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.79   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.79   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
85.2
alkaline phosphatase measurement
2
1
1
10.2
81.7
serum alanine aminotransferase measurement
2
1
1
9.1
79.7
low density lipoprotein cholesterol measurement
3
1
3
76.5
apolipoprotein B measurement
1
1
1
69.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
85.2
alkaline phosphatase measurement
1
10.2
81.7
serum alanine aminotransferase measurement
1
9.1
79.7
low density lipoprotein cholesterol measurement
3
76.5
apolipoprotein B measurement
1
69.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heat shock factor binding protein 1
VGNC:5799
739742
Mouse
MGI:1915446
68196
Rat
RGD:628632
286899
Dog
heat shock factor binding protein 1
VGNC:41795
100856736
Horse
heat shock factor binding protein 1
VGNC:18878
100055805
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heat shock factor binding protein 1
Mouse
Rat
Dog
heat shock factor binding protein 1
Horse
heat shock factor binding protein 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75506-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Attenuation phase (R-HSA-3371568)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Attenuation phase
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
HSF1 activation
Name
Explore in Pharos
Explore in Source
Attenuation phase
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
HSF1 activation
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (33)
1 – 10 of 33
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.999999975
p_ni:  2.5e-8
Score:  0.457
Data Source:  BioPlex,STRINGDB
WASHC3
Tdark
Novelty:  0.18307321
p_int:  0.999999973
p_ni:  2.4e-8
p_wrong:  2e-9
Score:  0.91
Data Source:  BioPlex,STRINGDB
STX11
Tbio
Novelty:  0.01670743
p_int:  0.999953639
p_ni:  0.000034748
p_wrong:  0.000011613
Data Source:  BioPlex
IFT57
Tbio
Novelty:  0.03373199
p_int:  0.999908901
p_ni:  0.000064966
p_wrong:  0.000026133
Data Source:  BioPlex
S100A4
Tchem
Novelty:  0.00136919
p_int:  0.999689118
p_ni:  0.000310882
Data Source:  BioPlex
CCHCR1
Tbio
Novelty:  0.03045656
p_int:  0.999093362
p_ni:  0.000906594
p_wrong:  4.3e-8
Data Source:  BioPlex
BORCS6
Tdark
Novelty:  0.83789033
p_int:  0.998457387
p_ni:  0.001542606
p_wrong:  6e-9
Data Source:  BioPlex
BLOC1S6
Tbio
Novelty:  0.01845286
p_int:  0.997927329
p_ni:  0.002072671
Data Source:  BioPlex
FAM9C
Tdark
Novelty:  0.86727989
p_int:  0.997146071
p_ni:  0.002853926
p_wrong:  3e-9
Data Source:  BioPlex
BSPRY
Tdark
Novelty:  0.38200913
p_int:  0.995341746
p_ni:  0.004658254
p_wrong:  1e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  10.79

PubMed score by year
PubTator Score  11.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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