Protein Summary
Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control. This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been obse ...more
- ENST00000230056
- ENSP00000230056
- ENSG00000112312
- ENST00000356509
- ENSP00000348902
- ENST00000620958
- ENSP00000477506
- Gem
- MGORS6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.92 | ||
transcription factor perturbation | 0.84 | ||
transcription factor binding site profile | 0.81 | ||
co-expressed gene | 0.79 | ||
kinase perturbation | 0.76 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 253.66 (req: < 5)
Gene RIFs: 58 (req: <= 3)
Antibodies: 366 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 253.66 (req: >= 5)
Gene RIFs: 58 (req: > 3)
Antibodies: 366 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | geminin, DNA replication inhibitor | VGNC:7891 | 462477 | |||||
Macaque | geminin, DNA replication inhibitor | 708416 | ||||||
Mouse | MGI:1927344 | 57441 | ||||||
Rat | RGD:1308137 | 291137 | ||||||
Dog | geminin, DNA replication inhibitor | VGNC:41291 | 478739 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | geminin, DNA replication inhibitor | |||||
Macaque | geminin, DNA replication inhibitor | |||||
Mouse | ||||||
Rat | ||||||
Dog | geminin, DNA replication inhibitor | |||||
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (10)
Reactome (9)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 9
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of the pre-replicative complex | ||||
Reactome | Assembly of the pre-replicative complex | ||||
Reactome | CDT1 association with the CDC6:ORC:origin complex | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of the pre-replicative complex | ||||
Assembly of the pre-replicative complex | ||||
CDT1 association with the CDC6:ORC:origin complex | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Gene Ontology Terms (17)
Functions (4)
Components (4)
Processes (9)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (278)
1 – 10 of 278
CCNA2
Novelty: 0.00049887
p_int: 0.999999999
p_ni: 1e-9
Score: 0.943
Data Source: BioPlex,STRINGDB
CDT1
Novelty: 0.00398013
p_int: 0.999999982
p_ni: 1.6e-8
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
NPHP3
Novelty: 0.02857926
p_int: 0.99999989
p_ni: 1.1e-7
Data Source: BioPlex
MID2
Family: Enzyme
Novelty: 0.01349913
p_int: 0.999999528
p_ni: 4.69e-7
p_wrong: 3e-9
Score: 0.186
Data Source: BioPlex,STRINGDB
E2F5
Family: TF
Novelty: 0.00674159
p_int: 0.999999516
p_ni: 4.62e-7
p_wrong: 2.2e-8
Score: 0.407
Data Source: BioPlex,STRINGDB
MSL1
Novelty: 3.71231442
p_int: 0.999998826
p_ni: 5.28e-7
p_wrong: 6.46e-7
Data Source: BioPlex
CKS1B
Family: Enzyme
Novelty: 0.00766779
p_int: 0.999998686
p_ni: 0.000001314
Score: 0.869
Data Source: BioPlex,STRINGDB
CDK2
Family: Kinase
Novelty: 0.00032118
p_int: 0.999996265
p_ni: 0.000003735
Score: 0.876
Data Source: BioPlex,STRINGDB
STN1
Novelty: 0.01309587
p_int: 0.999989292
p_ni: 0.000010708
Score: 0.417
Data Source: BioPlex,STRINGDB
MTMR1
Family: Enzyme
Novelty: 0.06694505
p_int: 0.999986361
p_ni: 0.000013639
Data Source: BioPlex
Publication Statistics
PubMed Score 253.66
PubMed score by year
PubTator Score 142.49
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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UniProt Keyword