Tbio GMNN Geminin

Protein Summary

Description

Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control. This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• O75496
• B3KMM8
• Q9H1Z1

Gene Name

• GMNN

Ensembl ID

• ENST00000230056
• ENSP00000230056
• ENSG00000112312
• ENST00000356509
• ENSP00000348902
• ENST00000620958
• ENSP00000477506

Symbol

• Gem
• MGORS6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.92
transcription factor perturbation	0.84
transcription factor binding site profile	0.81
co-expressed gene	0.79
kinase perturbation	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 286.22   (req: < 5)

Gene RIFs: 58   (req: <= 3)

Antibodies: 366   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 286.22   (req: >= 5)

Gene RIFs: 58   (req: > 3)

Antibodies: 366   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0