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Tbio
GMNN
Geminin

Protein Summary
Description
Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control. This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been obse ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230056
  • ENSP00000230056
  • ENSG00000112312
  • ENST00000356509
  • ENSP00000348902
  • ENST00000620958
  • ENSP00000477506

Symbol
  • Gem
  • MGORS6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.92
transcription factor perturbation
0.84
transcription factor binding site profile
0.81
co-expressed gene
0.79
kinase perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.28   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 366   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.28   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 366   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (278)
CCNA2
Tchem
Novelty:  0.00049887
p_int:  0.999999999
p_ni:  1e-9
Score:  0.943
Data Source:  BioPlex,STRINGDB
CDT1
Tbio
Novelty:  0.00398013
p_int:  0.999999982
p_ni:  1.6e-8
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NPHP3
Tbio
Novelty:  0.02857926
p_int:  0.99999989
p_ni:  1.1e-7
Data Source:  BioPlex
MID2
Tbio
Family:  Enzyme
Novelty:  0.01349913
p_int:  0.999999528
p_ni:  4.69e-7
p_wrong:  3e-9
Score:  0.186
Data Source:  BioPlex,STRINGDB
E2F5
Tbio
Family:  TF
Novelty:  0.00674159
p_int:  0.999999516
p_ni:  4.62e-7
p_wrong:  2.2e-8
Score:  0.407
Data Source:  BioPlex,STRINGDB
MSL1
Tbio
Novelty:  3.71231442
p_int:  0.999998826
p_ni:  5.28e-7
p_wrong:  6.46e-7
Data Source:  BioPlex
CKS1B
Tbio
Family:  Enzyme
Novelty:  0.00766779
p_int:  0.999998686
p_ni:  0.000001314
Score:  0.869
Data Source:  BioPlex,STRINGDB
CDK2
Tchem
Family:  Kinase
Novelty:  0.00032118
p_int:  0.999996265
p_ni:  0.000003735
Score:  0.876
Data Source:  BioPlex,STRINGDB
STN1
Tbio
Novelty:  0.01309587
p_int:  0.999989292
p_ni:  0.000010708
Score:  0.417
Data Source:  BioPlex,STRINGDB
MTMR1
Tbio
Family:  Enzyme
Novelty:  0.06694505
p_int:  0.999986361
p_ni:  0.000013639
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Activation of the pre-replicative complex (R-HSA-68962)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the pre-replicative complex
Reactome
Assembly of the pre-replicative complex
Reactome
CDT1 association with the CDC6:ORC:origin complex
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Activation of the pre-replicative complex
Assembly of the pre-replicative complex
CDT1 association with the CDC6:ORC:origin complex
Cell Cycle
Cell Cycle, Mitotic
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
2
1
2
83.5
lymphocyte count
2
1
2
80.6
neutrophil percentage of leukocytes
2
1
2
80.3
HbA1c measurement
1
1
1
52.4
neutrophil count
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
2
83.5
lymphocyte count
2
80.6
neutrophil percentage of leukocytes
2
80.3
HbA1c measurement
1
52.4
neutrophil count
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
geminin, DNA replication inhibitor
VGNC:7891
462477
Macaque
geminin, DNA replication inhibitor
708416
Mouse
MGI:1927344
57441
Rat
RGD:1308137
291137
Dog
geminin, DNA replication inhibitor
VGNC:41291
478739
Species
Name
OMA
EggNOG
Inparanoid
Chimp
geminin, DNA replication inhibitor
Macaque
geminin, DNA replication inhibitor
Mouse
Rat
Dog
geminin, DNA replication inhibitor
Publication Statistics
PubMed Score 257.28
PubMed score by year
PubTator Score 142.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title