Tbio SRSF10 Serine/arginine-rich splicing factor 10

Protein Summary

Description

Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250). This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• O75494
• A6NFM6
• A6NI42
• A6NIU7
• B4DJP9
• O60572
• Q5JRH9
• Q5JRI0
• Q5JRI2
• Q5JRI3
• Q5JRI4
• Q96G09
• Q96P17

Gene Name

• SRSF10

Ensembl ID

• ENST00000343255
• ENSP00000344149
• ENSG00000188529
• ENST00000344989
• ENSP00000342913
• ENST00000374452
• ENSP00000363576
• ENST00000453840
• ENSP00000388991
• ENST00000484146
• ENSP00000419813
• ENST00000492112
• ENSP00000420195

Symbol

• FUSIP1
• FUSIP2
• SFRS13A
• TASR
• NSSR
• TASR
• SRp38
• TASR1
• TASR2
• FUSIP1
• FUSIP2
• SFRS13
• SRrp40
• SFRS13A
• PPP1R149

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.93
virus perturbation	0.9
transcription factor binding site profile	0.87
ligand (protein) perturbation	0.83
microRNA	0.8

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Serine/arginine-rich Splicing Factor 10

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Serine/arginine-rich Splicing Factor 10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.67   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 233   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.67   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (188)

Explore Interacting Targets

1 – 10 of 188

• See Interactions on String-DB

U2AF2

Tbio

Novelty:  0.00590935

p_int:  0.990000998

p_ni:  0.009999002

Score:  0.988

Data Source:  BioPlex,STRINGDB

LUC7L2

Tdark

Novelty:  0.36989457

p_int:  0.987919193

p_ni:  0.012080807

Score:  0.44

Data Source:  BioPlex,STRINGDB

CLK2

Tchem

Family:  Kinase

Novelty:  0.13068449

p_int:  0.98248913

p_ni:  0.01751087

Score:  0.751

Data Source:  BioPlex,STRINGDB

SNIP1

Tbio

Novelty:  0.01865867

p_int:  0.975614047

p_ni:  0.024385953

Score:  0.633

Data Source:  BioPlex,STRINGDB

NKAPD1

Tdark

Novelty:  1.56979675

p_int:  0.963834473

p_ni:  0.036165526

Score:  0.221

Data Source:  BioPlex,STRINGDB

SAP18

Tbio

Family:  Enzyme

Novelty:  0.03918373

p_int:  0.96225494

p_ni:  0.03774506

p_wrong:  1e-9

Score:  0.786

Data Source:  BioPlex,STRINGDB

SNRNP70

Tbio

Novelty:  0.00116631

p_int:  0.946654467

p_ni:  0.053345532

p_wrong:  1e-9

Score:  0.97

Data Source:  BioPlex,STRINGDB

ZC3H18

Tdark

Novelty:  0.3515546

p_int:  0.91630121

p_ni:  0.08369879

Score:  0.548

Data Source:  BioPlex,STRINGDB

CLK3

Tchem

Family:  Kinase

Novelty:  0.03466191

p_int:  0.906368954

p_ni:  0.093631046

Score:  0.845

Data Source:  BioPlex,STRINGDB

CBLL2

Tdark

Family:  Enzyme

Novelty:  0.27990611

p_int:  0.904643408

p_ni:  0.095356592

Score:  0.204

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (4)

KEGG (1)

WikiPathways (1)

Metabolism of RNA (R-HSA-8953854)

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Reactome	mRNA Splicing	188 targets	R-HSA-72172
Reactome	mRNA Splicing - Major Pathway	180 targets	R-HSA-72163

Name	Explore in Pharos	Explore in Source
Metabolism of RNA	686 targets	R-HSA-8953854
Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
mRNA Splicing	188 targets	R-HSA-72172
mRNA Splicing - Major Pathway	180 targets	R-HSA-72163

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (19)

Functions (3)

Components (5)

Processes (11)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
RNA binding	Inferred from Direct Assay (IDA)	UniProtKB
RS domain binding	Non-traceable Author Statement (NAS)	UniProtKB
unfolded protein binding	Non-traceable Author Statement (NAS)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
eosinophil count	EFO_0004842	3	3	3		91.9
eosinophil percentage of leukocytes	EFO_0007991	2	2	2		85.5
lymphocyte count	EFO_0004587	1	1	1		59
eosinophil percentage of granulocytes	EFO_0007996	1	1	1		35
red blood cell distribution width	EFO_0005192	1	1	1		17.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
eosinophil count	EFO_0004842	3		91.9
eosinophil percentage of leukocytes	EFO_0007991	2		85.5
lymphocyte count	EFO_0004587	1		59
eosinophil percentage of granulocytes	EFO_0007996	1		35
red blood cell distribution width	EFO_0005192	1		17.4

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Cytoplasm
mRNA processing
mRNA splicing
Nucleus
Phosphoprotein
Reference proteome
RNA-binding

GWAS Trait Find Similar Targets

No Header	No Header
appendicular lean mass
eosinophil count
eosinophil percentage of granulocytes
eosinophil percentage of leukocytes
lymphocyte count
lymphocyte percentage of leukocytes
physical activity measurement
psychotic symptoms
red blood cell distribution width

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
liver/biliary system phenotype
mortality/aging
muscle phenotype

IDG Resources

No IDG generated resources found

Orthologs (5)

1 – 5 of 5

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	serine/arginine-rich splicing factor 10		705832
Mouse	serine/arginine-rich splicing factor 10	MGI:1333805	14105
Rat	serine and arginine rich splicing factor 10	RGD:1311067	362630
Horse	serine and arginine rich splicing factor 10 [Source:HGNC Symbol;Acc:HGNC:16713]
Xenopus	serine/arginine-rich splicing factor 10	XB-GENE-492982	496509

Species	Name	OMA	EggNOG	Inparanoid
Macaque	serine/arginine-rich splicing factor 10
Mouse	serine/arginine-rich splicing factor 10
Rat	serine and arginine rich splicing factor 10
Horse	serine and arginine rich splicing factor 10 [Source:HGNC Symbol;Acc:HGNC:16713]
Xenopus	serine/arginine-rich splicing factor 10

Publication Statistics

PubMed Score 90.67

PubMed score by year

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PubTator Score 45.48

PubTator score by year

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Related Publications

Text Mined References (36)

GeneRif Annotations (11)

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PMID	Year	Title