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Tchem
CA11
Carbonic anhydrase-related protein 11

Protein Summary
Description
Does not have a catalytic activity. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000084798
  • ENSP00000084798
  • ENSG00000063180

Symbol
  • CARP2
  • CA-RP
  • CA-XI
  • CARP-2
  • CARPX1
  • CA-RP II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.75
transcription factor binding site profile
0.71
transcription factor
0.64
tissue
0.6
PubMedID
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.86   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.86   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (23)
ANTXR1
Tbio
Novelty:  0.00508081
p_int:  0.995536308
p_ni:  0.001188929
p_wrong:  0.003274763
Score:  0.169
Data Source:  BioPlex,STRINGDB
CRP
Tbio
Novelty:  0.00001517
p_int:  0.99541121
p_ni:  0.000771799
p_wrong:  0.003816991
Score:  0.169
Data Source:  BioPlex,STRINGDB
INSL5
Tbio
Novelty:  0.04351334
p_int:  0.966934039
p_ni:  0.000119795
p_wrong:  0.032946166
Data Source:  BioPlex
TAZ
Tbio
Novelty:  0.00372301
p_int:  0.930444272
p_ni:  0.000079733
p_wrong:  0.069475995
Score:  0.15
Data Source:  BioPlex,STRINGDB
THRSP
Tbio
Novelty:  0.00938864
Score:  0.72
Data Source:  STRINGDB
CYP24A1
Tchem
Family:  Enzyme
Novelty:  0.00107155
Score:  0.669
Data Source:  STRINGDB
SNRPB
Tbio
Novelty:  0.01503535
Score:  0.641
Data Source:  STRINGDB
SLC4A4
Tbio
Family:  Transporter
Novelty:  0.00352439
Score:  0.589
Data Source:  STRINGDB
THRA
Tclin
Family:  NR
Novelty:  0.00171027
Score:  0.565
Data Source:  STRINGDB
UHMK1
Tbio
Family:  Kinase
Novelty:  0.04117277
Score:  0.559
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (77)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
4
7
6
16.2
99.6
serum gamma-glutamyl transferase measurement
3
5
4
2.3
98.9
low density lipoprotein cholesterol measurement
5
8
12
98.5
apolipoprotein B measurement
2
3
3
95.7
vitamin B12 measurement
3
3
2
70.2
93.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
6
16.2
99.6
serum gamma-glutamyl transferase measurement
4
2.3
98.9
low density lipoprotein cholesterol measurement
12
98.5
apolipoprotein B measurement
3
95.7
vitamin B12 measurement
2
70.2
93.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carbonic anhydrase 11
VGNC:10159
747478
Macaque
carbonic anhydrase 11
718066
Mouse
MGI:1336193
12348
Rat
RGD:735155
308588
Dog
carbonic anhydrase 11
VGNC:38606
484400
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carbonic anhydrase 11
Macaque
carbonic anhydrase 11
Mouse
Rat
Dog
carbonic anhydrase 11
Publication Statistics
PubMed Score 6.86
PubMed score by year
PubTator Score 33.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title