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Tclin
NDUFS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

Protein Summary
Description
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I). Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency.[provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263774
  • ENSP00000263774
  • ENSG00000213619
  • ENST00000534716
  • ENSP00000434970
  • ENST00000645714
  • ENSP00000496383
  • ENSG00000285387
  • ENST00000646736
  • ENSP00000494074

Symbol
  • CI-30
  • MC1DN8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
co-expressed gene
0.97
kinase perturbation
0.97
histone modification site profile
0.91
small molecule perturbation
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.48   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 265   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.48   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
1
1
1
87.8
comparative body size at age 10, self-reported
1
1
1
63.9
body height
1
1
1
59.2
waist-hip ratio
1
1
1
44
insomnia measurement
1
1
0
1
25.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
1
87.8
comparative body size at age 10, self-reported
1
63.9
body height
1
59.2
waist-hip ratio
1
44
insomnia measurement
0
1
25.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase core subunit S3
VGNC:6492
451175
Macaque
protein tyrosine phosphatase, mitochondrial 1
713104
Mouse
MGI:1915599
68349
Rat
RGD:1309406
295923
Dog
NADH:ubiquinone oxidoreductase core subunit S3
VGNC:43708
475978
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase core subunit S3
Macaque
protein tyrosine phosphatase, mitochondrial 1
Mouse
Rat
Dog
NADH:ubiquinone oxidoreductase core subunit S3
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75489-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Protein-Protein Interactions (226)
1 – 10 of 226
NDUFA12
Tclin
Family: Enzyme
Novelty: 0.04679316
p_int: 0.999998038
p_ni: 0.000001962
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB8
Tclin
Family: Enzyme
Novelty: 0.019021
p_int: 0.999992161
p_ni: 0.000007824
p_wrong: 1.5e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFS4
Tclin
Family: Enzyme
Novelty: 0.00787292
p_int: 0.999989397
p_ni: 0.000010602
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB6
Tclin
Family: Enzyme
Novelty: 0.075245
p_int: 0.999974034
p_ni: 0.000025956
p_wrong: 9e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB9
Tclin
Family: Enzyme
Novelty: 0.00715628
p_int: 0.99992386
p_ni: 0.00007614
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFS6
Tclin
Family: Enzyme
Novelty: 0.07910252
p_int: 0.999865525
p_ni: 0.000134475
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB5
Tclin
Family: Enzyme
Novelty: 0.0257403
p_int: 0.999431196
p_ni: 0.000568804
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB3
Tclin
Family: Enzyme
Novelty: 0.13020753
p_int: 0.999098682
p_ni: 0.000901315
p_wrong: 3e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFV3
Tclin
Family: Enzyme
Novelty: 0.15352039
p_int: 0.999085805
p_ni: 0.000914196
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFV2
Tclin
Family: Enzyme
Novelty: 0.02240263
p_int: 0.999077408
p_ni: 0.000922592
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  44.48

PubMed score by year
PubTator Score  40.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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