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Tbio
GPC4
Glypican-4

Protein Summary
Description
Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity). Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370828
  • ENSP00000359864
  • ENSG00000076716

Symbol
  • K-glypican
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.97
PubMedID
0.91
interacting protein
0.89
transcription factor perturbation
0.88
disease perturbation
0.74


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.19   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 375   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.19   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 375   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glypican 4
VGNC:1371
473788
Macaque
glypican 4
706665
Mouse
MGI:104902
14735
Rat
RGD:1359399
317322
Dog
glypican 4
VGNC:41374
492144
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glypican 4
Macaque
glypican 4
Mouse
Rat
Dog
glypican 4
Pathways (82)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Defective B3GALT6 causes EDSP2 and SEMDJL1
Reactome
Defective B3GAT3 causes JDSSDHD
Reactome
Defective B4GALT7 causes EDS, progeroid type
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate/dermatan sulfate metabolism
Defective B3GALT6 causes EDSP2 and SEMDJL1
Defective B3GAT3 causes JDSSDHD
Defective B4GALT7 causes EDS, progeroid type
Protein-Protein Interactions (128)
1 – 10 of 128
GPC6
Tbio
Novelty: 0.01951872
p_int: 0.999999995
p_ni: 5e-9
Score: 0.984
Data Source: BioPlex,STRINGDB
HADHA
Tbio
Novelty: 0.00385746
p_int: 0.999684372
p_ni: 0.000315628
Data Source: BioPlex
CAMKV
Tbio
Family: Kinase
Novelty: 0.17794181
p_int: 0.999058706
p_ni: 0.000941294
Score: 0.157
Data Source: BioPlex,STRINGDB
SCGB2A1
Tbio
Novelty: 0.01902973
p_int: 0.997821117
p_ni: 0.002178883
Data Source: BioPlex
GPR183
Tchem
Family: GPCR
Novelty: 0.02005679
p_int: 0.993478154
p_ni: 0.006521846
Score: 0.518
Data Source: BioPlex,STRINGDB
SPCS2
Tdark
Family: Enzyme
Novelty: 0.21358992
p_int: 0.990302956
p_ni: 0.009697044
Data Source: BioPlex
SCGB2A2
Tbio
Novelty: 0.01594053
p_int: 0.9675112
p_ni: 0.0324888
Data Source: BioPlex
MPPE1
Tbio
Family: Enzyme
Novelty: 0.16027847
p_int: 0.966606992
p_ni: 0.033393008
Data Source: BioPlex
MAN1A1
Tbio
Family: Enzyme
Novelty: 0.00645679
p_int: 0.880773331
p_ni: 0.119226669
Data Source: BioPlex
ADAM21
Tdark
Family: Enzyme
Novelty: 0.16068055
p_int: 0.773901687
p_ni: 0.226098313
Score: 0.2
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  75.19

PubMed score by year
PubTator Score  31.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer