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Tbio
TADA2A
Transcriptional adapter 2-alpha

Protein Summary
Description
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376). Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000617828
  • ENSP00000482484
  • ENSG00000277104
  • ENST00000622522
  • ENSP00000481283
  • ENST00000633468
  • ENSP00000488016
  • ENST00000633584
  • ENSP00000487973

Symbol
  • TADA2L
  • ADA2
  • ADA2A
  • KL04P
  • hADA2
  • TADA2L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
molecular function
0.9
protein domain
0.85
kinase perturbation
0.76
transcription factor binding site profile
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.3   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.3   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
1
2
82.4
lymphocyte count
2
2
2
81.7
platelet crit
2
2
2
75.9
platelet count
2
2
2
71.7
myeloid white cell count
1
1
1
70.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
82.4
lymphocyte count
2
81.7
platelet crit
2
75.9
platelet count
2
71.7
myeloid white cell count
1
70.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2144471
217031
Rat
RGD:1309959
360581
Dog
transcriptional adaptor 2A
VGNC:47070
480596
Horse
transcriptional adaptor 2A
VGNC:23845
100057641
Cow
transcriptional adaptor 2A
VGNC:35565
505401
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
transcriptional adaptor 2A
Horse
transcriptional adaptor 2A
Cow
transcriptional adaptor 2A
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75478-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Gene Ontology Terms (15)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (114)
1 – 10 of 114
DR1
Tbio
Novelty:  0.00138571
p_int:  0.99999999
p_ni:  1e-8
Score:  0.961
Data Source:  BioPlex,STRINGDB
TADA3
Tbio
Novelty:  0.01743814
p_int:  0.999999984
p_ni:  1.6e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
MBIP
Tbio
Novelty:  0.05807454
p_int:  0.999999981
p_ni:  1.9e-8
Score:  0.988
Data Source:  BioPlex,STRINGDB
WDR5
Tchem
Novelty:  0.0059945
p_int:  0.999999771
p_ni:  2.29e-7
Score:  0.979
Data Source:  BioPlex,STRINGDB
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
p_int:  0.999997186
p_ni:  0.000002796
p_wrong:  1.8e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
IKZF5
Tbio
Family:  TF
Novelty:  0.36596327
p_int:  0.99999543
p_ni:  0.00000457
Score:  0.566
Data Source:  BioPlex,STRINGDB
PSME3
Tbio
Novelty:  0.01051254
p_int:  0.99701555
p_ni:  0.002983858
p_wrong:  5.92e-7
Score:  0.221
Data Source:  BioPlex,STRINGDB
CARD8
Tbio
Family:  Enzyme
Novelty:  0.0146799
p_int:  0.996578137
p_ni:  0.003421543
p_wrong:  3.21e-7
Score:  0.552
Data Source:  BioPlex,STRINGDB
PSMC3
Tbio
Family:  Enzyme
Novelty:  0.04026019
p_int:  0.994775345
p_ni:  0.005224655
Data Source:  BioPlex
PCBD1
Tbio
Family:  Enzyme
Novelty:  0.01564376
p_int:  0.99374266
p_ni:  0.006252829
p_wrong:  0.00000451
Data Source:  BioPlex
Publication Statistics
PubMed Score  11.30

PubMed score by year
PubTator Score  109.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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