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Tchem
PSIP1
PC4 and SFRS1-interacting protein

Protein Summary
Description
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380715
  • ENSP00000370091
  • ENSG00000164985
  • ENST00000380716
  • ENSP00000370092
  • ENST00000380733
  • ENSP00000370109
  • ENST00000380738
  • ENSP00000370114
  • ENST00000397519
  • ENSP00000380653

Symbol
  • DFS70
  • LEDGF
  • PSIP2
  • p52
  • p75
  • PAIP
  • DFS70
  • LEDGF
  • PSIP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
transcription factor perturbation
0.94
disease perturbation
0.83
ligand (protein) perturbation
0.83
microRNA
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 580.43   (req: < 5)
Gene RIFs: 97   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 580.43   (req: >= 5)
Gene RIFs: 97   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (19)
1 – 5 of 19
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (28)
2-LTR circle formation (R-HSA-164843)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
2-LTR circle formation
Reactome
APOBEC3G mediated resistance to HIV-1 infection
Reactome
Autointegration results in viral DNA circles
Reactome
Disease
Reactome
Early Phase of HIV Life Cycle
Name
Explore in Pharos
Explore in Source
2-LTR circle formation
APOBEC3G mediated resistance to HIV-1 infection
Autointegration results in viral DNA circles
Disease
Early Phase of HIV Life Cycle
Gene Ontology Terms (17)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (119)
1 – 10 of 119
HDGFL2
Tbio
Family: Epigenetic
Novelty: 0.11846257
p_int: 0.905642084
p_ni: 0.094357916
Score: 0.159
Data Source: BioPlex,STRINGDB
POGZ
Tbio
Novelty: 0.03603188
Score: 0.986
Data Source: STRINGDB
MEN1
Tchem
Novelty: 0.00059287
Score: 0.916
Data Source: STRINGDB
KMT2A
Tchem
Family: Epigenetic
Novelty: 0.00192554
Score: 0.833
Data Source: STRINGDB
SRSF1
Tbio
Novelty: 0.00074446
Score: 0.826
Data Source: STRINGDB
EXOSC5
Tbio
Family: Enzyme
Novelty: 0.03352493
Score: 0.798
Data Source: STRINGDB
RBBP8
Tbio
Family: Enzyme
Novelty: 0.0044233
Score: 0.762
Data Source: STRINGDB
CDCA7L
Tbio
Novelty: 0.04191594
Score: 0.727
Data Source: STRINGDB
KMT2B
Tbio
Family: Epigenetic
Novelty: 0.00593529
Score: 0.706
Data Source: STRINGDB
SUMO1
Tbio
Novelty: 0.00137629
Score: 0.706
Data Source: STRINGDB
Publication Statistics
PubMed Score  580.43

PubMed score by year
PubTator Score  644.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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