PSIP1
PC4 and SFRS1-interacting protein
Protein Summary
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.
- ENST00000380715
- ENSP00000370091
- ENSG00000164985
- ENST00000380716
- ENSP00000370092
- ENST00000380733
- ENSP00000370109
- ENST00000380738
- ENSP00000370114
- ENST00000397519
- ENSP00000380653
- DFS70
- LEDGF
- PSIP2
- p52
- p75
- PAIP
- DFS70
- LEDGF
- PSIP2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.97 | ||
transcription factor perturbation | 0.94 | ||
disease perturbation | 0.83 | ||
ligand (protein) perturbation | 0.83 | ||
microRNA | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 654.4 (req: < 5)
Gene RIFs: 108 (req: <= 3)
Antibodies: 210 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 654.4 (req: >= 5)
Gene RIFs: 108 (req: > 3)
Antibodies: 210 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0