You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LGR5
Leucine-rich repeat-containing G-protein coupled receptor 5

Protein Summary
Description
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intest ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266674
  • ENSP00000266674
  • ENSG00000139292
  • ENST00000536515
  • ENSP00000443033
  • ENST00000540815
  • ENSP00000441035

Symbol
  • GPR49
  • GPR67
  • FEX
  • HG38
  • GPR49
  • GPR67
  • GRP49
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
PubMedID
0.87
ligand (protein)
0.85
histone modification site profile
0.75
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1009.1   (req: < 5)
Gene RIFs: 128   (req: <= 3)
Antibodies: 748   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1009.1   (req: >= 5)
Gene RIFs: 128   (req: > 3)
Antibodies: 748   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Regulation of FZD by ubiquitination (R-HSA-4641263)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Regulation of FZD by ubiquitination
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
TCF dependent signaling in response to WNT
Name
Explore in Pharos
Explore in Source
Regulation of FZD by ubiquitination
Signal Transduction
Signaling by WNT
TCF dependent signaling in response to WNT
Protein-Protein Interactions (142)
1 – 10 of 142
RSPO1
Tbio
Novelty: 0.00365075
Score: 0.997
Data Source: Reactome,STRINGDB
RNF43
Tbio
Family: Enzyme
Novelty: 0.01258908
Score: 0.992
Data Source: Reactome,STRINGDB
ZNRF3
Tbio
Family: Enzyme
Novelty: 0.03351825
Score: 0.987
Data Source: Reactome,STRINGDB
RSPO2
Tbio
Novelty: 0.0188211
Score: 0.981
Data Source: Reactome,STRINGDB
RSPO3
Tbio
Novelty: 0.02321039
Score: 0.972
Data Source: Reactome,STRINGDB
RSPO4
Tbio
Novelty: 0.05670413
Score: 0.961
Data Source: Reactome,STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.915
Data Source: STRINGDB
LGR4
Tbio
Family: GPCR
Novelty: 0.01180123
Score: 0.912
Data Source: STRINGDB
LGR6
Tbio
Family: GPCR
Novelty: 0.02186397
Score: 0.908
Data Source: STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.906
Data Source: STRINGDB
Publication Statistics
PubMed Score  1009.10

PubMed score by year
PubTator Score  315.4

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: