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Tbio
E2F6
Transcription factor E2F6

Protein Summary
Description
Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase. This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in other family members, and contains a modular suppression domain that functions in the inhibition of transcription. It interacts in a complex wit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307236
  • ENSP00000302159
  • ENSG00000169016
  • ENST00000381525
  • ENSP00000370936
  • ENST00000542100
  • ENSP00000446315
  • ENST00000546212
  • ENSP00000438864

Symbol
  • E2F-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
microRNA
0.83
transcription factor binding site profile
0.83
disease perturbation
0.74
histone modification site profile
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.97   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 302   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.97   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
55.2
1
2
0
1.2
50.6
electrocardiography
1
1
3
45.2
1
1
0
1.1
17.8
low density lipoprotein cholesterol measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
55.2
0
1.2
50.6
electrocardiography
3
45.2
0
1.1
17.8
low density lipoprotein cholesterol measurement
1
15.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
E2F transcription factor 6
VGNC:230
470148
Macaque
E2F transcription factor 6
697311
Mouse
MGI:1354159
50496
Rat
RGD:631412
313978
Dog
E2F transcription factor 6
VGNC:40168
609996
Species
Name
OMA
EggNOG
Inparanoid
Chimp
E2F transcription factor 6
Macaque
E2F transcription factor 6
Mouse
Rat
Dog
E2F transcription factor 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75461-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
G1/S Transition
Reactome
G1/S-Specific Transcription
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
G1/S Transition
G1/S-Specific Transcription
Gene expression (Transcription)
Gene Ontology Terms (17)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (163)
1 – 10 of 163
PCGF6
Tbio
Novelty:  0.07032909
p_int:  1
Score:  0.985
Data Source:  BioPlex,Reactome,STRINGDB
L3MBTL2
Tbio
Family:  Epigenetic
Novelty:  0.11193867
p_int:  0.999999999
p_ni:  1e-9
Score:  0.993
Data Source:  BioPlex,Reactome,STRINGDB
TFDP2
Tbio
Family:  TF
Novelty:  0.14331363
p_int:  0.999999994
p_ni:  6e-9
Score:  0.889
Data Source:  BioPlex,Reactome,STRINGDB
MAX
Tbio
Family:  TF
Novelty:  0.00799068
p_int:  0.999998849
p_ni:  0.000001147
p_wrong:  4e-9
Score:  0.928
Data Source:  BioPlex,Reactome,STRINGDB
RYBP
Tbio
Novelty:  0.01140945
p_int:  0.999996351
p_ni:  0.000003649
Score:  0.983
Data Source:  BioPlex,STRINGDB
COMMD8
Tdark
Novelty:  0.33240242
p_int:  0.999990675
p_ni:  0.000009298
p_wrong:  2.7e-8
Score:  0.644
Data Source:  BioPlex,STRINGDB
COMMD1
Tbio
Novelty:  0.01349432
p_int:  0.999982944
p_ni:  0.000017056
Score:  0.666
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999973172
p_ni:  0.000026828
Score:  0.561
Data Source:  BioPlex,STRINGDB
COMMD6
Tbio
Novelty:  0.11854363
p_int:  0.999968221
p_ni:  0.000031779
Score:  0.745
Data Source:  BioPlex,STRINGDB
MIER2
Tbio
Novelty:  0.85226416
p_int:  0.999921367
p_ni:  0.000077905
p_wrong:  7.28e-7
Score:  0.761
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  109.97

PubMed score by year
PubTator Score  32.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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