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Tbio
KATNA1
Katanin p60 ATPase-containing subunit A1

Protein Summary
Description
Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, wh ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335643
  • ENSP00000335180
  • ENSG00000186625
  • ENST00000335647
  • ENSP00000335106
  • ENST00000367411
  • ENSP00000356381
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
molecular function
0.99
disease perturbation
0.9
protein domain
0.85
cellular component
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.45   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 196   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.45   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
KATNBL1
Tdark
Novelty:  1.43589506
p_int:  1
Score:  0.951
Data Source:  BioPlex,STRINGDB
KATNB1
Tbio
Novelty:  0.08472625
p_int:  0.999999962
p_ni:  3.8e-8
Score:  0.996
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.999979877
p_ni:  0.00002012
p_wrong:  3e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
CCT5
Tbio
Novelty:  0.02369118
p_int:  0.999815151
p_ni:  0.00018475
p_wrong:  9.9e-8
Data Source:  BioPlex
INPP5K
Tbio
Family:  Enzyme
Novelty:  0.07282504
p_int:  0.999787683
p_ni:  0.000212256
p_wrong:  6e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
PFDN4
Tbio
Novelty:  0.02133605
p_int:  0.99966499
p_ni:  0.00033501
Score:  0.259
Data Source:  BioPlex,STRINGDB
CCT7
Tbio
Novelty:  0.02247038
p_int:  0.999402364
p_ni:  0.000597636
Score:  0.195
Data Source:  BioPlex,STRINGDB
ARIH1
Tbio
Family:  Enzyme
Novelty:  0.0258739
p_int:  0.996883747
p_ni:  0.003047757
p_wrong:  0.000068497
Data Source:  BioPlex
LACRT
Tbio
Novelty:  0.03333799
p_int:  0.996751361
p_ni:  0.003248639
Data Source:  BioPlex
ASB3
Tbio
Novelty:  0.15921018
p_int:  0.995313335
p_ni:  0.001111765
p_wrong:  0.0035749
Score:  0.42
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain stem volume measurement
1
1
0
6.7
49.5
1
1
0
1.1
31.4
1
1
0
1.1
7.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain stem volume measurement
0
6.7
49.5
0
1.1
31.4
0
1.1
7.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
katanin catalytic subunit A1
VGNC:9591
748379
Macaque
katanin catalytic subunit A1
698291
Mouse
MGI:1344353
23924
Rat
RGD:1303062
292464
Dog
katanin catalytic subunit A1
VGNC:42216
476240
Species
Name
OMA
EggNOG
Inparanoid
Chimp
katanin catalytic subunit A1
Macaque
katanin catalytic subunit A1
Mouse
Rat
Dog
katanin catalytic subunit A1
Publication Statistics
PubMed Score 16.45
PubMed score by year
PubTator Score 7.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title