You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MED24
Mediator of RNA polymerase II transcription subunit 24

Protein Summary
Description
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms hav ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356271
  • ENSP00000348610
  • ENSG00000008838
  • ENST00000394127
  • ENSP00000377685
  • ENST00000394128
  • ENSP00000377686

Symbol
  • ARC100
  • CRSP4
  • DRIP100
  • KIAA0130
  • THRAP4
  • TRAP100
  • MED5
  • CRSP4
  • ARC100
  • THRAP4
  • CRSP100
  • DRIP100
  • TRAP100
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.88
molecular function
0.88
disease perturbation
0.79
biological process
0.77
protein complex
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.31   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.31   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (45)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
11
14
22
99.9
leukocyte count
11
13
27
99.7
myeloid white cell count
5
7
7
99.6
lymphocyte percentage of leukocytes
2
6
7
98.9
neutrophil percentage of leukocytes
2
5
6
98.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
22
99.9
leukocyte count
27
99.7
myeloid white cell count
7
99.6
lymphocyte percentage of leukocytes
7
98.9
neutrophil percentage of leukocytes
6
98.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 24
VGNC:9372
454642
Macaque
mediator complex subunit 24
699536
Mouse
MGI:1344385
23989
Rat
RGD:1564565
619436
Dog
mediator complex subunit 24
VGNC:43132
480529
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 24
Macaque
mediator complex subunit 24
Mouse
Rat
Dog
mediator complex subunit 24
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75448-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
Metabolism of lipids
Gene Ontology Terms (12)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (93)
1 – 10 of 93
MED19
Tbio
Family:  Enzyme
Novelty:  0.03926689
p_int:  0.999999946
p_ni:  5.4e-8
Score:  0.994
Data Source:  BioPlex,STRINGDB
MED21
Tbio
Family:  Enzyme
Novelty:  0.06996616
p_int:  0.999999912
p_ni:  8.8e-8
Score:  0.991
Data Source:  BioPlex,STRINGDB
MED17
Tbio
Family:  Enzyme
Novelty:  0.02984503
p_int:  0.999999719
p_ni:  2.82e-7
Score:  0.994
Data Source:  BioPlex,STRINGDB
MED18
Tbio
Family:  Enzyme
Novelty:  0.04066825
p_int:  0.999999542
p_ni:  4.58e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED1
Tbio
Family:  Enzyme
Novelty:  0.00852082
p_int:  0.999999449
p_ni:  5.51e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED28
Tbio
Family:  Enzyme
Novelty:  0.00362108
p_int:  0.99999931
p_ni:  6.9e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED10
Tdark
Family:  Enzyme
Novelty:  0.02988632
p_int:  0.999999142
p_ni:  8.59e-7
Score:  0.989
Data Source:  BioPlex,STRINGDB
CCNC
Tbio
Novelty:  0.00585842
p_int:  0.999999108
p_ni:  8.92e-7
Score:  0.988
Data Source:  BioPlex,STRINGDB
MED20
Tbio
Family:  Enzyme
Novelty:  0.02039559
p_int:  0.999998891
p_ni:  0.00000111
Score:  0.992
Data Source:  BioPlex,STRINGDB
MED4
Tbio
Family:  Enzyme
Novelty:  0.01200585
p_int:  0.999998446
p_ni:  0.000001555
Score:  0.994
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  18.31

PubMed score by year
PubTator Score  15.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: