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Tbio
SAP30
Histone deacetylase complex subunit SAP30

Protein Summary
Description
Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones. Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296504
  • ENSP00000296504
  • ENSG00000164105
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
hub protein
0.92
virus perturbation
0.92
histone modification site profile
0.89
transcription factor binding site profile
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.61   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.61   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (129)
1 – 10 of 129
SINHCAF
Tdark
Novelty:  0.18692832
p_int:  0.999999935
p_ni:  6.5e-8
Score:  0.967
Data Source:  BioPlex,STRINGDB
ING2
Tchem
Family:  Epigenetic
Novelty:  0.02424031
p_int:  0.999987456
p_ni:  0.000012544
Score:  0.994
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999980313
p_ni:  0.000019687
Score:  0.981
Data Source:  BioPlex,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.99997631
p_ni:  0.000023688
p_wrong:  2e-9
Score:  0.985
Data Source:  BioPlex,STRINGDB
ZNF704
Tdark
Novelty:  0.34442716
p_int:  0.999454617
p_ni:  0.000545383
Score:  0.682
Data Source:  BioPlex,STRINGDB
MXD3
Tbio
Family:  TF
Novelty:  0.07436584
p_int:  0.983478682
p_ni:  0.016521307
p_wrong:  1.1e-8
Score:  0.535
Data Source:  BioPlex,STRINGDB
PHF23
Tbio
Family:  Epigenetic
Novelty:  0.17699844
p_int:  0.958566718
p_ni:  0.041316914
p_wrong:  0.000116368
Score:  0.305
Data Source:  BioPlex,STRINGDB
MAX
Tbio
Family:  TF
Novelty:  0.00799068
p_int:  0.941979529
p_ni:  0.040064512
p_wrong:  0.017955958
Score:  0.9
Data Source:  BioPlex,STRINGDB
SIN3A
Tbio
Novelty:  0.00747207
Score:  0.996
Data Source:  STRINGDB
SUDS3
Tbio
Family:  Enzyme
Novelty:  0.03837881
Score:  0.991
Data Source:  STRINGDB
Pathways (48)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
HDACs deacetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Epigenetic regulation of gene expression
Gene expression (Transcription)
HDACs deacetylate histones
Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
1
1
11.1
chin morphology measurement
1
1
0
1.1
10
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
11.1
chin morphology measurement
0
1.1
10
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Sin3A associated protein 30
VGNC:2004
471351
Macaque
Sin3A associated protein 30
696519
Mouse
MGI:1929129
60406
Rat
Dog
Sin3A associated protein 30
VGNC:45860
607359
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Sin3A associated protein 30
Macaque
Sin3A associated protein 30
Mouse
Rat
Dog
Sin3A associated protein 30
Publication Statistics
PubMed Score 26.61
PubMed score by year
PubTator Score 14.01
PubTator score by year