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Tbio
MAF
Transcription factor Maf

Protein Summary
Description
Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) si ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326043
  • ENSP00000327048
  • ENSG00000178573
  • ENST00000393350
  • ENSP00000377019

Symbol
  • CCA4
  • AYGRP
  • c-MAF
  • CTRCT21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.99
transcription factor perturbation
0.96
protein domain
0.85
cell type or tissue
0.81
gene perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2226.51   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 408   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2226.51   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 408   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (186)
IL4
Tbio
Novelty:  0.00005852
Score:  0.979
Data Source:  STRINGDB
MYB
Tbio
Family:  TF
Novelty:  0.00092053
Score:  0.969
Data Source:  STRINGDB
IRF4
Tbio
Family:  TF
Novelty:  0.00192973
Score:  0.958
Data Source:  STRINGDB
NFE2
Tchem
Family:  TF
Novelty:  0.00321017
Score:  0.95
Data Source:  STRINGDB
IL13
Tbio
Novelty:  0.00021435
Score:  0.947
Data Source:  STRINGDB
NFATC2
Tbio
Family:  TF
Novelty:  0.00312526
Score:  0.94
Data Source:  STRINGDB
NFATC1
Tchem
Family:  TF
Novelty:  0.00130337
Score:  0.94
Data Source:  STRINGDB
AR
Tclin
Family:  NR
Novelty:  0.00013531
Score:  0.915
Data Source:  STRINGDB
NFATC3
Tbio
Family:  TF
Novelty:  0.00602983
Score:  0.915
Data Source:  STRINGDB
HDAC3
Tclin
Family:  Epigenetic
Novelty:  0.00393172
Score:  0.912
Data Source:  STRINGDB
Pathways (78)
Gene expression (Transcription) (R-HSA-74160)

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1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX2 regulates bone development
Reactome
RUNX2 regulates osteoblast differentiation
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX2 regulates bone development
RUNX2 regulates osteoblast differentiation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
79.5
C-reactive protein measurement
1
2
2
75.4
2
3
0
1.1
72.5
blood protein measurement
2
2
2
66.2
eosinophil count
2
2
2
64.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
79.5
C-reactive protein measurement
2
75.4
0
1.1
72.5
blood protein measurement
2
66.2
eosinophil count
2
64.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:96909
17132
Rat
RGD:3034
54267
Cow
MAF bZIP transcription factor
782481
Xenopus
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
XB-GENE-6053271
613051
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
MAF bZIP transcription factor
Xenopus
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
Publication Statistics
PubMed Score 2226.51
PubMed score by year
PubTator Score 419.30
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title