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Tbio
MAF
Transcription factor Maf

Protein Summary
Description
Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) si ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326043
  • ENSP00000327048
  • ENSG00000178573
  • ENST00000393350
  • ENSP00000377019

Symbol
  • CCA4
  • AYGRP
  • c-MAF
  • CTRCT21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.99
transcription factor perturbation
0.96
protein domain
0.85
cell type or tissue
0.81
gene perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2171.13   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 408   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2171.13   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 408   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
64.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
64.7
Pathways (78)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX2 regulates bone development
Reactome
RUNX2 regulates osteoblast differentiation
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX2 regulates bone development
RUNX2 regulates osteoblast differentiation
Gene Ontology Terms (15)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (186)
1 – 10 of 186
IL4
Tbio
Novelty: 0.00005852
Score: 0.979
Data Source: STRINGDB
MYB
Tbio
Family: TF
Novelty: 0.00092053
Score: 0.969
Data Source: STRINGDB
IRF4
Tbio
Family: TF
Novelty: 0.00192973
Score: 0.958
Data Source: STRINGDB
NFE2
Tbio
Family: TF
Novelty: 0.00321017
Score: 0.95
Data Source: STRINGDB
IL13
Tbio
Novelty: 0.00021435
Score: 0.947
Data Source: STRINGDB
NFATC2
Tbio
Family: TF
Novelty: 0.00312526
Score: 0.94
Data Source: STRINGDB
NFATC1
Tbio
Family: TF
Novelty: 0.00130337
Score: 0.94
Data Source: STRINGDB
AR
Tclin
Family: NR
Novelty: 0.00013531
Score: 0.915
Data Source: STRINGDB
NFATC3
Tbio
Family: TF
Novelty: 0.00602983
Score: 0.915
Data Source: STRINGDB
HDAC3
Tclin
Family: Epigenetic
Novelty: 0.00393172
Score: 0.912
Data Source: STRINGDB
Publication Statistics
PubMed Score  2171.13

PubMed score by year
PubTator Score  419.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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