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Tclin
NDUFB1
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1

Protein Summary
Description
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329559
  • ENSP00000330787
  • ENSG00000183648
  • ENST00000553514
  • ENSP00000451090
  • ENST00000555441
  • ENSP00000450776
  • ENST00000605997
  • ENSP00000475170
  • ENST00000617122
  • ENSP00000483888

Symbol
  • MNLL
  • CI-MNLL
  • CI-SGDH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.78
virus perturbation
0.68
histone modification site profile
0.65
disease perturbation
0.62
tissue
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.55   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.55   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at onset
1
1
0
6.5
33.3
Myopia
1
1
0
6.5
33.3
refractive error measurement
1
1
0
6.5
33.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at onset
0
6.5
33.3
Myopia
0
6.5
33.3
refractive error measurement
0
6.5
33.3
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit B1
VGNC:7518
453115
Horse
NADH:ubiquinone oxidoreductase subunit B1
100630425
Cow
NADH:ubiquinone oxidoreductase subunit B1
327690
Opossum
NADH:ubiquinone oxidoreductase subunit B1
100016103
Anole lizard
NADH:ubiquinone oxidoreductase subunit B1 [Source:HGNC Symbol;Acc:HGNC:7695]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit B1
Horse
NADH:ubiquinone oxidoreductase subunit B1
Cow
NADH:ubiquinone oxidoreductase subunit B1
Opossum
NADH:ubiquinone oxidoreductase subunit B1
Anole lizard
NADH:ubiquinone oxidoreductase subunit B1 [Source:HGNC Symbol;Acc:HGNC:7695]
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75438-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (101)
1 – 10 of 101
NDUFA7
Tclin
Family: Enzyme
Novelty: 0.16417588
p_int: 0.999843092
p_ni: 0.000129756
p_wrong: 0.000027152
Score: 0.997
Data Source: BioPlex,STRINGDB
ECSIT
Tbio
Novelty: 0.04690184
p_int: 0.999841407
p_ni: 0.0001325
p_wrong: 0.000026093
Score: 0.98
Data Source: BioPlex,STRINGDB
NDUFS6
Tclin
Family: Enzyme
Novelty: 0.07910252
p_int: 0.99978066
p_ni: 0.000198787
p_wrong: 0.000020552
Score: 0.997
Data Source: BioPlex,STRINGDB
NDUFV3
Tclin
Family: Enzyme
Novelty: 0.15352039
p_int: 0.999041111
p_ni: 0.000035949
p_wrong: 0.00092294
Score: 0.993
Data Source: BioPlex,STRINGDB
NDUFS5
Tclin
Family: Enzyme
Novelty: 0.13274675
p_int: 0.996532606
p_ni: 0.000335357
p_wrong: 0.003132037
Score: 0.998
Data Source: BioPlex,STRINGDB
NDUFB3
Tclin
Family: Enzyme
Novelty: 0.13020753
p_int: 0.99377171
p_ni: 0.006157061
p_wrong: 0.000071228
Score: 0.997
Data Source: BioPlex,STRINGDB
SPPL2B
Tbio
Family: Enzyme
Novelty: 0.0274774
p_int: 0.981697817
p_ni: 0.000103864
p_wrong: 0.018198319
Data Source: BioPlex
C3AR1
Tchem
Family: GPCR
Novelty: 0.00527301
p_int: 0.980331834
p_ni: 0.000190558
p_wrong: 0.019477608
Data Source: BioPlex
NDUFA8
Tclin
Family: Enzyme
Novelty: 0.05772867
p_int: 0.97930834
p_ni: 0.000051827
p_wrong: 0.020639832
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB11
Tclin
Family: Enzyme
Novelty: 0.0401232
p_int: 0.967162777
p_ni: 0.000106108
p_wrong: 0.032731115
Score: 0.993
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  9.55

PubMed score by year
PubTator Score  3.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer