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Tbio
VPS26A
Vacuolar protein sorting-associated protein 26A

Protein Summary
Description
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme re ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263559
  • ENSP00000263559
  • ENSG00000122958
  • ENST00000373382
  • ENSP00000362480
  • ENST00000395098
  • ENSP00000378532

Symbol
  • VPS26
  • HB58
  • PEP8A
  • VPS26
  • Hbeta58
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
kinase perturbation
0.96
histone modification site profile
0.89
disease perturbation
0.79
co-expressed gene
0.76


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.26   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.26   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (163)
VPS29
Tbio
Novelty:  0.01335106
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
VPS26B
Tdark
Novelty:  0.25702869
p_int:  1
Score:  0.974
Data Source:  BioPlex,STRINGDB
TBC1D5
Tbio
Novelty:  0.11547525
p_int:  0.999999991
p_ni:  9e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
VPS35
Tbio
Novelty:  0.00729892
p_int:  0.999997494
p_ni:  0.000002506
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
MCM7
Tbio
Novelty:  0.0017984
p_int:  0.999983391
p_ni:  0.000016609
Score:  0.814
Data Source:  BioPlex,STRINGDB
SNX3
Tbio
Novelty:  0.02703152
p_int:  0.999454945
p_ni:  0.000544696
p_wrong:  3.6e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
LRRC73
Tdark
Novelty:  48
p_int:  0.998459735
p_ni:  0.001540265
Score:  0.177
Data Source:  BioPlex,STRINGDB
GPSM3
Tbio
Novelty:  0.01632501
p_int:  0.98639053
p_ni:  0.013609049
p_wrong:  4.22e-7
Data Source:  BioPlex
CITED1
Tbio
Novelty:  0.01956689
p_int:  0.965453434
p_ni:  0.034546401
p_wrong:  1.65e-7
Data Source:  BioPlex
IFT20
Tbio
Novelty:  0.03005088
p_int:  0.935322845
p_ni:  0.064675485
p_wrong:  0.00000167
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
WNT ligand biogenesis and trafficking
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by WNT
WNT ligand biogenesis and trafficking
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
12
12
99
lymphocyte count
3
3
3
88.3
aspartate aminotransferase measurement
2
2
1
7.7
86.4
birth weight
4
3
4
83.5
sex hormone-binding globulin measurement
3
2
3
78
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
12
99
lymphocyte count
3
88.3
aspartate aminotransferase measurement
1
7.7
86.4
birth weight
4
83.5
sex hormone-binding globulin measurement
3
78
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
VPS26, retromer complex component A
VGNC:7273
748846
Macaque
VPS26, retromer complex component A
717371
Mouse
MGI:1353654
30930
Rat
RGD:1359254
361846
Dog
VPS26, retromer complex component A
VGNC:48280
479233
Species
Name
OMA
EggNOG
Inparanoid
Chimp
VPS26, retromer complex component A
Macaque
VPS26, retromer complex component A
Mouse
Rat
Dog
VPS26, retromer complex component A
Publication Statistics
PubMed Score 50.26
PubMed score by year
PubTator Score 33.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title