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Tbio
MTX2
Metaxin-2

Protein Summary
Description
Involved in transport of proteins into the mitochondrion. The protein encoded by this gene is highly similar to the metaxin 2 protein from mouse, which has been shown to interact with the mitochondrial membrane protein metaxin 1. Because of this similarity, it is thought that the encoded protein is peripherally associated with the cytosolic face of the outer mitochondrial membrane, and that it is involved in the import of proteins into the mitochondrion. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249442
  • ENSP00000249442
  • ENSG00000128654
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
virus perturbation
0.92
disease perturbation
0.87
transcription factor binding site profile
0.81
histone modification site profile
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.67   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.67   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Alopecia
1
1
1
24.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Alopecia
1
24.7
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
metaxin 2
VGNC:2024
459767
Macaque
metaxin 2
701294
Mouse
MGI:1859652
53375
Rat
RGD:1306473
288150
Dog
metaxin 2
VGNC:53101
478811
Species
Name
OMA
EggNOG
Inparanoid
Chimp
metaxin 2
Macaque
metaxin 2
Mouse
Rat
Dog
metaxin 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75431-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Cristae formation (R-HSA-8949613)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cristae formation
Reactome
Mitochondrial biogenesis
Reactome
Mitochondrial protein import
Reactome
Organelle biogenesis and maintenance
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Cristae formation
Mitochondrial biogenesis
Mitochondrial protein import
Organelle biogenesis and maintenance
Protein localization
Protein-Protein Interactions (68)
1 – 10 of 68
MTX3
Tdark
Novelty: 0.06082176
p_int: 0.999988192
p_ni: 0.000011808
Score: 0.744
Data Source: BioPlex,STRINGDB
CARD19
Tbio
Family: Enzyme
Novelty: 0.18215136
p_int: 0.999941459
p_ni: 0.00000988
p_wrong: 0.000048662
Score: 0.817
Data Source: BioPlex,STRINGDB
CHCHD6
Tbio
Novelty: 0.12379343
p_int: 0.987848031
p_ni: 0.012151969
Score: 0.997
Data Source: BioPlex,STRINGDB
SAMM50
Tbio
Novelty: 0.00553631
p_int: 0.98657066
p_ni: 0.01342934
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
CHCHD3
Tbio
Novelty: 0.05341939
p_int: 0.984710353
p_ni: 0.015289647
Score: 0.994
Data Source: BioPlex,STRINGDB
CD244
Tbio
Novelty: 0.01137579
p_int: 0.958717936
p_ni: 0.041282064
Score: 0.823
Data Source: BioPlex,STRINGDB
IMMT
Tbio
Novelty: 0.00260309
p_int: 0.891858381
p_ni: 0.108141619
Score: 0.997
Data Source: BioPlex,STRINGDB
MINOS1
Tdark
Novelty: 0.40437095
Score: 0.99
Data Source: STRINGDB
APOOL
Tbio
Novelty: 0.08233023
Score: 0.978
Data Source: STRINGDB
MIC13
Tbio
Novelty: 0.03686888
Score: 0.974
Data Source: STRINGDB
Publication Statistics
PubMed Score  48.67

PubMed score by year
PubTator Score  18.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer