Protein Summary
Involved in transport of proteins into the mitochondrion. The protein encoded by this gene is highly similar to the metaxin 2 protein from mouse, which has been shown to interact with the mitochondrial membrane protein metaxin 1. Because of this similarity, it is thought that the encoded protein is peripherally associated with the cytosolic face of the outer mitochondrial membrane, and that it is involved in the import of proteins into the mitochondrion. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jun 2009]
- ENST00000249442
- ENSP00000249442
- ENSG00000128654
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.99 | ||
virus perturbation | 0.92 | ||
disease perturbation | 0.87 | ||
transcription factor binding site profile | 0.81 | ||
histone modification site profile | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 52.9 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 164 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 52.9 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 164 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (68)
MTX3
Novelty: 0.06082176
p_int: 0.999988192
p_ni: 0.000011808
Score: 0.744
Data Source: BioPlex,STRINGDB
CARD19
Family: Enzyme
Novelty: 0.18215136
p_int: 0.999941459
p_ni: 0.00000988
p_wrong: 0.000048662
Score: 0.817
Data Source: BioPlex,STRINGDB
CHCHD6
Novelty: 0.12379343
p_int: 0.987848031
p_ni: 0.012151969
Score: 0.997
Data Source: BioPlex,STRINGDB
SAMM50
Novelty: 0.00553631
p_int: 0.98657066
p_ni: 0.01342934
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
CHCHD3
Novelty: 0.05341939
p_int: 0.984710353
p_ni: 0.015289647
Score: 0.994
Data Source: BioPlex,STRINGDB
CD244
Novelty: 0.01137579
p_int: 0.958717936
p_ni: 0.041282064
Score: 0.823
Data Source: BioPlex,STRINGDB
IMMT
Novelty: 0.00260309
p_int: 0.891858381
p_ni: 0.108141619
Score: 0.997
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cristae formation | ||||
Reactome | Mitochondrial biogenesis | ||||
Reactome | Mitochondrial protein import | ||||
Reactome | Organelle biogenesis and maintenance | ||||
Reactome | Protein localization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cristae formation | ||||
Mitochondrial biogenesis | ||||
Mitochondrial protein import | ||||
Organelle biogenesis and maintenance | ||||
Protein localization | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Components (4)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | HPA | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
4 | 3 | 0 | 1.1 | 80.2 | |||||
glomerular filtration rate | 3 | 3 | 3 | 7.7 | 78.1 | ||||
2 | 2 | 0 | 1.3 | 74 | |||||
ovarian serous carcinoma | 3 | 2 | 0 | 1.1 | 73.4 | ||||
1 | 4 | 4 | 72.4 | ||||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 80.2 | |||||
glomerular filtration rate | 3 | 7.7 | 78.1 | ||||
0 | 1.3 | 74 | |||||
ovarian serous carcinoma | 0 | 1.1 | 73.4 | ||||
4 | 72.4 | ||||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | metaxin 2 | VGNC:2024 | 459767 | |||||
Macaque | metaxin 2 | 701294 | ||||||
Mouse | MGI:1859652 | 53375 | ||||||
Rat | RGD:1306473 | 288150 | ||||||
Dog | metaxin 2 | VGNC:53101 | 478811 | |||||
Publication Statistics
PubMed Score 52.90
PubMed score by year
PubTator Score 18.37
PubTator score by year
Related Publications
Text Mined References (11)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
|---|