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Tdark
FBXO24
F-box only protein 24

Protein Summary
Description
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000241071
  • ENSP00000241071
  • ENSG00000106336
  • ENST00000427939
  • ENSP00000416558
  • ENST00000465843
  • ENSP00000419602
  • ENST00000468962
  • ENSP00000420239

Symbol
  • FBX24
  • FBX24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.8
tissue sample
0.6
virus perturbation
0.59
transcription factor binding site profile
0.54
cell type or tissue
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.02   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.02   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
Score:  0.802
Data Source:  STRINGDB
ANKRD46
Tbio
Novelty:  0.06546845
Score:  0.78
Data Source:  STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.778
Data Source:  STRINGDB
ANKRD10
Tdark
Novelty:  0.6861542
Score:  0.755
Data Source:  STRINGDB
RNF214
Tdark
Novelty:  2.76722057
Score:  0.745
Data Source:  STRINGDB
NYAP2
Tdark
Family:  Enzyme
Novelty:  1.08965558
Score:  0.739
Data Source:  STRINGDB
FBXL19
Tbio
Novelty:  0.07526966
Score:  0.728
Data Source:  STRINGDB
ACAP1
Tbio
Novelty:  0.04481025
Score:  0.694
Data Source:  STRINGDB
NYAP1
Tdark
Family:  Enzyme
Novelty:  0.57209235
Score:  0.666
Data Source:  STRINGDB
CARS
Tchem
Family:  Enzyme
Novelty:  0.02078279
Score:  0.66
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
5
9
99
mean corpuscular hemoglobin concentration
5
4
5
98.9
mean corpuscular volume
5
7
7
98
erythrocyte count
6
3
6
97.2
hematocrit
6
9
10
97
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
9
99
mean corpuscular hemoglobin concentration
5
98.9
mean corpuscular volume
7
98
erythrocyte count
6
97.2
hematocrit
10
97
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box protein 24
VGNC:14001
739613
Macaque
F-box protein 24
721953
Mouse
MGI:1918426
71176
Rat
RGD:1305095
304374
Dog
F-box protein 24
VGNC:54025
608428
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box protein 24
Macaque
F-box protein 24
Mouse
Rat
Dog
F-box protein 24
Publication Statistics
PubMed Score 1.02
PubMed score by year
PubTator Score 0.67
PubTator score by year
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Related Publications
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PMID
Year
Title