You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CDC45
Cell division control protein 45 homolog

Protein Summary
Description
Required for initiation of chromosomal DNA replication. The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263201
  • ENSP00000263201
  • ENSG00000093009
  • ENST00000404724
  • ENSP00000384978
  • ENST00000407835
  • ENSP00000385240
  • ENST00000437685
  • ENSP00000405726

Symbol
  • CDC45L
  • CDC45L2
  • CDC45L
  • MGORS7
  • CDC45L2
  • PORC-PI-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
gene perturbation
0.92
transcription factor binding site profile
0.8
biological process
0.76
molecular function
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.83   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 321   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.83   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (22)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Activation of the pre-replicative complex
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Protein-Protein Interactions (328)
1 – 10 of 328
ORC1
Tbio
Novelty: 0.02913098
Score: 0.999
Data Source: STRINGDB
GINS4
Tbio
Novelty: 0.0316194
Score: 0.999
Data Source: Reactome,STRINGDB
MCM7
Tbio
Novelty: 0.0017984
Score: 0.999
Data Source: STRINGDB
GINS3
Tbio
Novelty: 0.02892519
Score: 0.999
Data Source: Reactome,STRINGDB
MCM5
Tbio
Novelty: 0.00716583
Score: 0.999
Data Source: STRINGDB
MCM2
Tbio
Novelty: 0.00276275
Score: 0.999
Data Source: STRINGDB
MCM3
Tbio
Novelty: 0.00593382
Score: 0.999
Data Source: STRINGDB
ORC2
Tbio
Novelty: 0.11963517
Score: 0.999
Data Source: STRINGDB
CDC6
Tbio
Novelty: 0.00219371
Score: 0.999
Data Source: Reactome,STRINGDB
MCM10
Tbio
Novelty: 0.0136058
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  186.83

PubMed score by year
PubTator Score  80.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer