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Tbio
CDC45
Cell division control protein 45 homolog

Protein Summary
Description
Required for initiation of chromosomal DNA replication. The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263201
  • ENSP00000263201
  • ENSG00000093009
  • ENST00000404724
  • ENSP00000384978
  • ENST00000407835
  • ENSP00000385240
  • ENST00000437685
  • ENSP00000405726

Symbol
  • CDC45L
  • CDC45L2
  • CDC45L
  • MGORS7
  • CDC45L2
  • PORC-PI-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
gene perturbation
0.92
transcription factor binding site profile
0.8
biological process
0.76
molecular function
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.9   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 321   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.9   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (328)
ORC1
Tbio
Novelty:  0.02913098
Score:  0.999
Data Source:  STRINGDB
GINS4
Tbio
Novelty:  0.0316194
Score:  0.999
Data Source:  Reactome,STRINGDB
MCM7
Tbio
Novelty:  0.0017984
Score:  0.999
Data Source:  STRINGDB
GINS3
Tbio
Novelty:  0.02892519
Score:  0.999
Data Source:  Reactome,STRINGDB
MCM5
Tbio
Novelty:  0.00716583
Score:  0.999
Data Source:  STRINGDB
MCM3
Tbio
Novelty:  0.00593382
Score:  0.999
Data Source:  STRINGDB
MCM2
Tbio
Novelty:  0.00276275
Score:  0.999
Data Source:  STRINGDB
ORC2
Tbio
Novelty:  0.11963517
Score:  0.999
Data Source:  STRINGDB
CDC6
Tbio
Novelty:  0.00219371
Score:  0.999
Data Source:  Reactome,STRINGDB
MCM10
Tbio
Novelty:  0.0136058
Score:  0.999
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (22)
Activation of ATR in response to replication stress (R-HSA-176187)

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Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Activation of the pre-replicative complex
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
5.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
5.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cell division cycle 45
VGNC:5243
458651
Macaque
cell division cycle 45
711800
Mouse
MGI:1338073
12544
Rat
RGD:1590928
287961
Dog
cell division cycle 45
VGNC:39007
486421
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cell division cycle 45
Macaque
cell division cycle 45
Mouse
Rat
Dog
cell division cycle 45
Publication Statistics
PubMed Score 191.90
PubMed score by year
PubTator Score 80.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title