Tbio CDC45 Cell division control protein 45 homolog

Protein Summary

Description

Required for initiation of chromosomal DNA replication. The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• O75419
• B4DDB4
• B4DDU3
• E9PDH7
• O60856
• Q20WK8
• Q6UW54
• Q9UP68

Gene Name

• CDC45

Ensembl ID

• ENST00000263201
• ENSP00000263201
• ENSG00000093009
• ENST00000404724
• ENSP00000384978
• ENST00000407835
• ENSP00000385240
• ENST00000437685
• ENSP00000405726

Symbol

• CDC45L
• CDC45L2
• CDC45L
• MGORS7
• CDC45L2
• PORC-PI-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
gene perturbation	0.92
transcription factor binding site profile	0.8
biological process	0.76
molecular function	0.76

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Replication Origin Binding Protein / Cell Division Control Protein 45 Homolog

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Replication Origin Binding Protein / Cell Division Control Protein 45 Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.9   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 321   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.9   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (328)

Explore Interacting Targets

1 – 10 of 328

• See Interactions on String-DB

ORC1

Tbio

Novelty:  0.02913098

Score:  0.999

Data Source:  STRINGDB

GINS4

Tbio

Novelty:  0.0316194

Score:  0.999

Data Source:  Reactome,STRINGDB

MCM7

Tbio

Novelty:  0.0017984

Score:  0.999

Data Source:  STRINGDB

GINS3

Tbio

Novelty:  0.02892519

Score:  0.999

Data Source:  Reactome,STRINGDB

MCM5

Tbio

Novelty:  0.00716583

Score:  0.999

Data Source:  STRINGDB

MCM3

Tbio

Novelty:  0.00593382

Score:  0.999

Data Source:  STRINGDB

MCM2

Tbio

Novelty:  0.00276275

Score:  0.999

Data Source:  STRINGDB

ORC2

Tbio

Novelty:  0.11963517

Score:  0.999

Data Source:  STRINGDB

CDC6

Tbio

Novelty:  0.00219371

Score:  0.999

Data Source:  Reactome,STRINGDB

MCM10

Tbio

Novelty:  0.0136058

Score:  0.999

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (22)

Reactome (15)

KEGG (1)

WikiPathways (6)

Activation of ATR in response to replication stress (R-HSA-176187)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of ATR in response to replication stress	37 targets	R-HSA-176187
Reactome	Activation of the pre-replicative complex	33 targets	R-HSA-68962
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle Checkpoints	272 targets	R-HSA-69620
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278

Name	Explore in Pharos	Explore in Source
Activation of ATR in response to replication stress	37 targets	R-HSA-176187
Activation of the pre-replicative complex	33 targets	R-HSA-68962
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle Checkpoints	272 targets	R-HSA-69620
Cell Cycle, Mitotic	495 targets	R-HSA-69278

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (21)

Functions (4)

Components (7)

Processes (10)

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1 – 4 of 4

GO Term	Evidence	Assigned by
3'-5' DNA helicase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
chromatin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA replication origin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
single-stranded DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
blood protein measurement	EFO_0007937	1	1	1		5.9

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
blood protein measurement	EFO_0007937	1		5.9

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UniProt Keyword Find Similar Targets

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3D-structure
Alternative splicing
Cell cycle
Complete proteome
Cytoplasm
Disease mutation
DNA replication
Dwarfism
Nucleus
Phosphoprotein

GWAS Trait Find Similar Targets

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blood protein measurement

MGI Phenotype Find Similar Targets

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cellular phenotype
embryo phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (16)

1 – 5 of 16

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cell division cycle 45	VGNC:5243	458651
Macaque	cell division cycle 45		711800
Mouse	cell division cycle 45	MGI:1338073	12544
Rat	cell division cycle 45	RGD:1590928	287961
Dog	cell division cycle 45	VGNC:39007	486421

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cell division cycle 45
Macaque	cell division cycle 45
Mouse	cell division cycle 45
Rat	cell division cycle 45
Dog	cell division cycle 45

Publication Statistics

PubMed Score 191.90

PubMed score by year

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PubTator Score 80.42

PubTator score by year

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Related Publications

Text Mined References (51)

GeneRif Annotations (28)

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PMID	Year	Title