Tbio CDC45 Cell division control protein 45 homolog

Protein Summary

Description

Required for initiation of chromosomal DNA replication. The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• O75419
• B4DDB4
• B4DDU3
• E9PDH7
• O60856
• Q20WK8
• Q6UW54
• Q9UP68

Gene Name

• CDC45

Ensembl ID

• ENST00000263201
• ENSP00000263201
• ENSG00000093009
• ENST00000404724
• ENSP00000384978
• ENST00000407835
• ENSP00000385240
• ENST00000437685
• ENSP00000405726

Symbol

• CDC45L
• CDC45L2
• CDC45L
• MGORS7
• CDC45L2
• PORC-PI-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
gene perturbation	0.92
transcription factor binding site profile	0.8
biological process	0.76
molecular function	0.76

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Replication Origin Binding Protein / Cell Division Control Protein 45 Homolog

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Replication Origin Binding Protein / Cell Division Control Protein 45 Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.46   (req: < 5)

Gene RIFs: 40   (req: <= 3)

Antibodies: 321   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.46   (req: >= 5)

Gene RIFs: 40   (req: > 3)

Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0