Tbio CDC45 Cell division control protein 45 homolog

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Replication Origin Binding Protein / Cell Division Control Protein 45 Homolog

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Replication Origin Binding Protein / Cell Division Control Protein 45 Homolog

Protein Summary

Description

Required for initiation of chromosomal DNA replication. The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• O75419
• B4DDB4
• B4DDU3
• E9PDH7
• O60856
• Q20WK8
• Q6UW54
• Q9UP68

Gene Name

• CDC45

Ensembl ID

• ENST00000263201
• ENSP00000263201
• ENSG00000093009
• ENST00000404724
• ENSP00000384978
• ENST00000407835
• ENSP00000385240
• ENST00000437685
• ENSP00000405726

Symbol

• CDC45L
• CDC45L2
• CDC45L
• MGORS7
• CDC45L2
• PORC-PI-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
gene perturbation	0.92
transcription factor binding site profile	0.8
biological process	0.76
molecular function	0.76

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.83   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 321   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.83   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (22)

Reactome (15)

KEGG (1)

WikiPathways (6)

Activation of ATR in response to replication stress (R-HSA-176187)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of ATR in response to replication stress	37 targets	R-HSA-176187
Reactome	Activation of the pre-replicative complex	33 targets	R-HSA-68962
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle Checkpoints	272 targets	R-HSA-69620
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278

Name	Explore in Pharos	Explore in Source
Activation of ATR in response to replication stress	37 targets	R-HSA-176187
Activation of the pre-replicative complex	33 targets	R-HSA-68962
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle Checkpoints	272 targets	R-HSA-69620
Cell Cycle, Mitotic	495 targets	R-HSA-69278

Gene Ontology Terms (21)

Functions (4)

Components (7)

Processes (10)

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10

1 – 4 of 4

GO Term	Evidence	Assigned by
3'-5' DNA helicase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
chromatin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA replication origin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
single-stranded DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (328)

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1 – 10 of 328

• See Interactions on String-DB

ORC1

Tbio

Novelty: 0.02913098

Score: 0.999

Data Source: STRINGDB

GINS4

Tbio

Novelty: 0.0316194

Score: 0.999

Data Source: Reactome,STRINGDB

MCM7

Tbio

Novelty: 0.0017984

Score: 0.999

Data Source: STRINGDB

GINS3

Tbio

Novelty: 0.02892519

Score: 0.999

Data Source: Reactome,STRINGDB

MCM5

Tbio

Novelty: 0.00716583

Score: 0.999

Data Source: STRINGDB

MCM2

Tbio

Novelty: 0.00276275

Score: 0.999

Data Source: STRINGDB

MCM3

Tbio

Novelty: 0.00593382

Score: 0.999

Data Source: STRINGDB

ORC2

Tbio

Novelty: 0.11963517

Score: 0.999

Data Source: STRINGDB

CDC6

Tbio

Novelty: 0.00219371

Score: 0.999

Data Source: Reactome,STRINGDB

MCM10

Tbio

Novelty: 0.0136058

Score: 0.999

Data Source: Reactome,STRINGDB

Publication Statistics

PubMed Score  186.83

PubMed score by year

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PubTator Score  80.42

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Alternative splicing
Cell cycle
Complete proteome
Cytoplasm
Disease mutation
DNA replication
Dwarfism
Nucleus
Phosphoprotein

MGI Phenotype Find Similar Targets

cellular phenotype
embryo phenotype
mortality/aging