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Tbio
POLQ
DNA polymerase theta

Protein Classes
Protein Summary
Description
DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA (PubMed:25642963, PubMed:25643323). MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation (PubMed:25642963, PubMed:25643323). POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends (PubMed:25642963). POLQ-mediated MMEJ may be required to promote the survival of cells with a compromised HR repair pathway, thereby preventing genomic havoc by resolving unrepaired lesions (By similarity). The polymerase acts by binding directly the 2 ends of resected double-strand breaks, allowing microhomologous sequences in the overhangs to form base pairs. It then extends each strand from the base-p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264233
  • ENSP00000264233
  • ENSG00000051341

Symbol
  • POLH
  • PRO0327
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.97
histone modification site profile
0.89
transcription factor binding site profile
0.72
cell line
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.37   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.37   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
DNA Double-Strand Break Repair (R-HSA-5693532)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
HDR through MMEJ (alt-NHEJ)
Reactome
Homology Directed Repair
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
HDR through MMEJ (alt-NHEJ)
Homology Directed Repair
Gene Ontology Terms (21)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (134)
1 – 10 of 134
RBBP8
Tbio
Family: Enzyme
Novelty: 0.0044233
Score: 0.951
Data Source: Reactome,STRINGDB
FEN1
Tchem
Family: Enzyme
Novelty: 0.00082515
Score: 0.943
Data Source: Reactome,STRINGDB
RAD51
Tchem
Novelty: 0.00011516
Score: 0.939
Data Source: STRINGDB
PARP2
Tclin
Family: Enzyme
Novelty: 0.00545618
Score: 0.935
Data Source: STRINGDB
PARP1
Tclin
Family: Enzyme
Novelty: 0.00033016
Score: 0.931
Data Source: Reactome,STRINGDB
NBN
Tbio
Novelty: 0.00759456
Score: 0.917
Data Source: Reactome,STRINGDB
MRE11
Tbio
Novelty: 0.01038348
Score: 0.915
Data Source: Reactome,STRINGDB
RAD50
Tbio
Novelty: 0.02161298
Score: 0.915
Data Source: Reactome,STRINGDB
FANCD2
Tbio
Novelty: 0.00316101
Score: 0.837
Data Source: STRINGDB
TOP2A
Tclin
Family: Enzyme
Novelty: 0.00122788
Score: 0.82
Data Source: STRINGDB
Publication Statistics
PubMed Score  67.37

PubMed score by year
PubTator Score  38.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer