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Tbio
PRPF40A
Pre-mRNA-processing factor 40 homolog A

Protein Summary
Description
Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000648940
  • ENSP00000497573
  • ENSG00000196504

Symbol
  • FBP11
  • FLAF1
  • FNBP3
  • HIP10
  • HYPA
  • HYPA
  • FBP11
  • FLAF1
  • FNBP3
  • HIP10
  • Prp40
  • FBP-11
  • HIP-10
  • NY-REN-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
transcription factor perturbation
0.98
ligand (protein) perturbation
0.83
virus perturbation
0.83
interacting protein
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.76   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.76   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0