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Tbio
PRPF40A
Pre-mRNA-processing factor 40 homolog A

Protein Summary
Description
Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000648940
  • ENSP00000497573
  • ENSG00000196504

Symbol
  • FBP11
  • FLAF1
  • FNBP3
  • HIP10
  • HYPA
  • HYPA
  • FBP11
  • FLAF1
  • FNBP3
  • HIP10
  • Prp40
  • FBP-11
  • HIP-10
  • NY-REN-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
transcription factor perturbation
0.98
ligand (protein) perturbation
0.83
virus perturbation
0.83
interacting protein
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.71   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.71   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
80.7
puberty onset measurement
1
1
1
63.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
80.7
puberty onset measurement
1
63.4
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Gene Ontology Terms (16)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (312)
1 – 10 of 312
JMJD6
Tbio
Family: Enzyme
Novelty: 0.00305479
p_int: 1
Score: 0.553
Data Source: BioPlex,STRINGDB
RBM25
Tbio
Novelty: 0.05557892
p_int: 0.999999941
p_ni: 6e-8
Score: 0.995
Data Source: BioPlex,STRINGDB
ZC3H18
Tdark
Novelty: 0.3515546
p_int: 0.999961876
p_ni: 0.000038124
Score: 0.458
Data Source: BioPlex,STRINGDB
TERF2
Tbio
Family: TF
Novelty: 0.01003649
p_int: 0.999957368
p_ni: 0.000042632
Score: 0.21
Data Source: BioPlex,STRINGDB
CCDC9
Tdark
Novelty: 0.73149492
p_int: 0.999947635
p_ni: 0.000052073
p_wrong: 2.92e-7
Score: 0.311
Data Source: BioPlex,STRINGDB
SAP18
Tbio
Family: Enzyme
Novelty: 0.03918373
p_int: 0.999946751
p_ni: 0.00005325
Score: 0.262
Data Source: BioPlex,STRINGDB
NCBP3
Tbio
Novelty: 0.07581882
p_int: 0.998866846
p_ni: 0.001133154
Score: 0.353
Data Source: BioPlex,STRINGDB
NKAP
Tbio
Novelty: 0.04982584
p_int: 0.998362015
p_ni: 0.001637985
Score: 0.817
Data Source: BioPlex,STRINGDB
PNN
Tbio
Novelty: 0.01395394
p_int: 0.998070857
p_ni: 0.001929143
Score: 0.696
Data Source: BioPlex,STRINGDB
SLC30A4
Tbio
Family: Transporter
Novelty: 0.02209
p_int: 0.997916892
p_ni: 0.002083107
p_wrong: 1e-9
Score: 0.191
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  111.71

PubMed score by year
PubTator Score  47.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer