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Tbio
DEAF1
Deformed epidermal autoregulatory factor 1 homolog

Protein Summary
Description
Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm. Transcriptional activator of EIF4G3. This gene encodes a zinc finger domain-containing protein that func ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.85
virus perturbation
0.79
gene perturbation
0.71
transcription factor binding site profile
0.71
cell type or tissue
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 303   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 303   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
Name
Explore in Pharos
Explore in Source
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
Gene Ontology Terms (22)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (50)
1 – 10 of 50
BSPRY
Tdark
Novelty: 0.40597143
p_int: 0.999997368
p_wrong: 0.000002632
Score: 0.282
Data Source: BioPlex,STRINGDB
ZMYND19
Tdark
Novelty: 0.42857143
Score: 0.819
Data Source: STRINGDB
ZMYND11
Tbio
Family: Epigenetic
Novelty: 0.0286523
Score: 0.8
Data Source: STRINGDB
HTR1A
Tclin
Family: GPCR
Novelty: 0.00019966
Score: 0.778
Data Source: STRINGDB
GATD1
Tdark
Family: Enzyme
Novelty: 1
Score: 0.741
Data Source: STRINGDB
RAN
Tbio
Family: Enzyme
Novelty: 0.00230621
Score: 0.74
Data Source: STRINGDB
EIF4G3
Tbio
Novelty: 0.04202311
Score: 0.715
Data Source: STRINGDB
AIRE
Tbio
Family: TF; Epigenetic
Novelty: 0.00109835
Score: 0.682
Data Source: STRINGDB
AGBL5
Tbio
Family: Enzyme
Novelty: 0.09110629
Score: 0.682
Data Source: STRINGDB
CC2D1A
Tbio
Novelty: 0.01893881
Score: 0.674
Data Source: STRINGDB
Publication Statistics
PubMed Score  60.00

PubMed score by year
PubTator Score  278.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer