Tbio DEAF1 Deformed epidermal autoregulatory factor 1 homolog

Protein Summary

Description

Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm. Transcriptional activator of EIF4G3. This gene encodes a zinc finger domain-containing protein that functions as a regulator of transcription. The encoded proteins binds to its own promoter as well as to that of several target genes. Activity of this protein is important in the regulation of embryonic development. Mutations in this gene have been found in individuals with autosomal dominant cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Uniprot Accession IDs

• O75398
• A8K1F8
• A8K5R8
• C7T5V5
• O15152
• O75399
• O75510
• O75511
• O75512
• O75513
• Q9UET1

Gene Name

• DEAF1

Ensembl ID

• ENST00000382409
• ENSP00000371846
• ENSG00000177030

Symbol

• SPN
• ZMYND5
• SPN
• NUDR
• MRD24
• ZMYND5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.85
virus perturbation	0.79
gene perturbation	0.71
transcription factor binding site profile	0.71
cell type or tissue	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.48   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 303   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.48   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 303   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0