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Tbio
SEC22B
Vesicle-trafficking protein SEC22b

Protein Summary
Description
SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000578049
  • ENSP00000463393
  • ENSG00000265808

Symbol
  • SEC22L1
  • ERS-24
  • SEC22L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
0.91
transcription factor perturbation
0.8
transcription factor binding site profile
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.24   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 192   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.24   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 192   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (251)
USE1
Tbio
Novelty:  0.00904756
p_int:  0.9999977
p_ni:  0.0000023
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
SCFD2
Tdark
Novelty:  0.38252131
p_int:  0.999997057
p_ni:  0.000002943
Score:  0.834
Data Source:  BioPlex,STRINGDB
NBAS
Tbio
Novelty:  0.01187862
p_int:  0.999995993
p_ni:  0.000004007
Score:  0.982
Data Source:  BioPlex,STRINGDB
STX18
Tbio
Novelty:  0.0259034
p_int:  0.999947318
p_ni:  0.000052682
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
RINT1
Tbio
Novelty:  0.04546291
p_int:  0.999943075
p_ni:  0.000056925
Score:  0.991
Data Source:  BioPlex,STRINGDB
BNIP1
Tbio
Novelty:  0.04601895
p_int:  0.999932207
p_ni:  0.000067793
Score:  0.986
Data Source:  BioPlex,Reactome,STRINGDB
BET1
Tdark
Novelty:  0.01791164
p_int:  0.999922949
p_ni:  0.000076954
p_wrong:  9.7e-8
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
STX5
Tbio
Novelty:  0.00964918
p_int:  0.999864755
p_ni:  0.000135245
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
GOSR1
Tbio
Novelty:  0.03139481
p_int:  0.999811668
p_ni:  0.000188332
Score:  0.995
Data Source:  BioPlex,STRINGDB
GOSR2
Tbio
Novelty:  0.02447711
p_int:  0.999808827
p_ni:  0.000189857
p_wrong:  0.000001316
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPII-mediated vesicle transport
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPII-mediated vesicle transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
1
2
13
eosinophil percentage of leukocytes
1
1
1
11.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
13
eosinophil percentage of leukocytes
1
11.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
SEC22 homolog B, vesicle trafficking protein
713856
Mouse
MGI:1338759
20333
Rat
RGD:1309988
310710
Dog
SEC22 homolog B, vesicle trafficking protein
475816
Horse
SEC22 homolog B, vesicle trafficking protein
100059997
Species
Name
OMA
EggNOG
Inparanoid
Macaque
SEC22 homolog B, vesicle trafficking protein
Mouse
Rat
Dog
SEC22 homolog B, vesicle trafficking protein
Horse
SEC22 homolog B, vesicle trafficking protein
Publication Statistics
PubMed Score 35.24
PubMed score by year
PubTator Score 13.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title