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Tchem
ULK1
Serine/threonine-protein kinase ULK1

Protein Summary
Description
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321867
  • ENSP00000324560
  • ENSG00000177169

Symbol
  • KIAA0722
  • ATG1
  • ATG1A
  • UNC51
  • hATG1
  • Unc51.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
biological process
0.92
protein domain
0.92
cellular component
0.86
small molecule
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 352.95   (req: < 5)
Gene RIFs: 103   (req: <= 3)
Antibodies: 796   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 352.95   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 796   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (154)
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.999999985
p_ni:  1.4e-8
p_wrong:  1e-9
Data Source:  BioPlex
ATG101
Tbio
Novelty:  0.03407206
p_int:  0.999999004
p_ni:  9.94e-7
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
WASHC3
Tdark
Novelty:  0.18307321
p_int:  0.99709725
p_ni:  0.000002745
p_wrong:  0.002900005
Score:  0.214
Data Source:  BioPlex,STRINGDB
ATG13
Tbio
Novelty:  0.00951471
Score:  0.999
Data Source:  Reactome,STRINGDB
RB1CC1
Tbio
Novelty:  0.00744817
Score:  0.999
Data Source:  Reactome,STRINGDB
MTOR
Tclin
Family:  Kinase
Novelty:  0.00012333
Score:  0.995
Data Source:  Reactome,STRINGDB
BECN1
Tbio
Novelty:  0.0003792
Score:  0.994
Data Source:  Reactome,STRINGDB
PIK3C3
Tchem
Family:  Kinase
Novelty:  0.00269825
Score:  0.99
Data Source:  Reactome,STRINGDB
ATG14
Tbio
Novelty:  0.00914791
Score:  0.986
Data Source:  Reactome,STRINGDB
MAP1LC3A
Tbio
Novelty:  0.00301583
Score:  0.984
Data Source:  STRINGDB
Pathways (22)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Reactome
Membrane Trafficking
Reactome
Mitophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Membrane Trafficking
Mitophagy
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (40)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
1
3
47.4
mean corpuscular volume
1
1
1
34.9
mean reticulocyte volume
1
1
1
34.7
mathematical ability
1
1
1
21.5
mean corpuscular hemoglobin concentration
1
1
1
17.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
47.4
mean corpuscular volume
1
34.9
mean reticulocyte volume
1
34.7
mathematical ability
1
21.5
mean corpuscular hemoglobin concentration
1
17.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
unc-51 like autophagy activating kinase 1
709746
Mouse
MGI:1270126
22241
Rat
RGD:1589743
360827
Dog
unc-51 like autophagy activating kinase 1
VGNC:48128
477437
Horse
unc-51 like autophagy activating kinase 1 [Source:HGNC Symbol;Acc:HGNC:12558]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
unc-51 like autophagy activating kinase 1
Mouse
Rat
Dog
unc-51 like autophagy activating kinase 1
Horse
unc-51 like autophagy activating kinase 1 [Source:HGNC Symbol;Acc:HGNC:12558]
Publication Statistics
PubMed Score 352.95
PubMed score by year
PubTator Score 245.09
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title