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Tbio
PEX14
Peroxisomal membrane protein PEX14

Protein Summary
Description
Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin. This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356607
  • ENSP00000349016
  • ENSG00000142655

Symbol
  • NAPP2
  • PBD13A
  • Pex14p
  • dJ734G22.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
virus perturbation
0.94
biological process
0.83
cellular component
0.8
transcription factor binding site profile
0.74


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.28   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.28   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (123)
IKZF5
Tbio
Family:  TF
Novelty:  0.36596327
p_int:  0.999949369
p_ni:  0.000050631
Data Source:  BioPlex
CROCC
Tbio
Novelty:  0.03718561
p_int:  0.999532474
p_ni:  0.000467523
p_wrong:  3e-9
Data Source:  BioPlex
CCL4
Tbio
Novelty:  0.00069278
p_int:  0.999095236
p_ni:  0.000904764
Score:  0.248
Data Source:  BioPlex,STRINGDB
HOMER3
Tbio
Novelty:  0.04408998
p_int:  0.998591363
p_ni:  0.001408637
Data Source:  BioPlex
FOXJ1
Tbio
Family:  TF
Novelty:  0.00778536
p_int:  0.991703632
p_ni:  0.008296368
Score:  0.175
Data Source:  BioPlex,STRINGDB
GPR156
Tdark
Family:  GPCR
Novelty:  0.39183023
p_int:  0.971942438
p_ni:  0.028057562
Data Source:  BioPlex
NEU2
Tbio
Family:  Enzyme
Novelty:  0.00460828
p_int:  0.960190093
p_ni:  0.039809907
Score:  0.177
Data Source:  BioPlex,STRINGDB
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.958356475
p_ni:  0.041643525
Data Source:  BioPlex
TP63
Tbio
Family:  TF
Novelty:  0.00336108
p_int:  0.937288335
p_ni:  0.062711665
Score:  0.169
Data Source:  BioPlex,STRINGDB
P4HA3
Tbio
Family:  Enzyme
Novelty:  0.03832564
p_int:  0.924375086
p_ni:  0.075624914
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Class I peroxisomal membrane protein import (R-HSA-9603798)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class I peroxisomal membrane protein import
Reactome
E3 ubiquitin ligases ubiquitinate target proteins
Reactome
Metabolism of proteins
Reactome
Peroxisomal protein import
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Class I peroxisomal membrane protein import
E3 ubiquitin ligases ubiquitinate target proteins
Metabolism of proteins
Peroxisomal protein import
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
3
3
94.9
2
2
0
1.1
81.6
heel bone mineral density
2
2
2
71.6
leukocyte count
1
1
1
64.9
red blood cell density measurement
1
1
1
63.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
3
94.9
0
1.1
81.6
heel bone mineral density
2
71.6
leukocyte count
1
64.9
red blood cell density measurement
1
63.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peroxisomal biogenesis factor 14
VGNC:1446
457929
Macaque
peroxisomal biogenesis factor 14
722675
Mouse
MGI:1927868
56273
Rat
RGD:68336
64460
Dog
centromere protein S
487450
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peroxisomal biogenesis factor 14
Macaque
peroxisomal biogenesis factor 14
Mouse
Rat
Dog
centromere protein S
Publication Statistics
PubMed Score 46.28
PubMed score by year
PubTator Score 43.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title