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Tchem
NCOR1
Nuclear receptor corepressor 1

Protein Summary
Description
Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing res ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268712
  • ENSP00000268712
  • ENSG00000141027
  • ENST00000395848
  • ENSP00000379189
  • ENST00000395851
  • ENSP00000379192

Symbol
  • KIAA1047
  • N-CoR
  • TRAC1
  • N-CoR1
  • hN-CoR
  • PPP1R109
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
biological process
0.99
molecular function
0.96
kinase perturbation
0.93


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 415.8   (req: < 5)
Gene RIFs: 85   (req: <= 3)
Antibodies: 381   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 415.8   (req: >= 5)
Gene RIFs: 85   (req: > 3)
Antibodies: 381   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
2
2
89.8
body mass index
2
1
2
83.5
sex hormone-binding globulin measurement
1
1
1
83.1
thyroxine measurement
1
1
1
59.5
lymphocyte count
1
1
1
31.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
89.8
body mass index
2
83.5
sex hormone-binding globulin measurement
1
83.1
thyroxine measurement
1
59.5
lymphocyte count
1
31.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor corepressor 1
468370
Macaque
nuclear receptor corepressor 1
696351
Mouse
MGI:1349717
20185
Dog
nuclear receptor corepressor 1
VGNC:43665
479515
Horse
nuclear receptor corepressor 1
VGNC:20602
100063285
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor corepressor 1
Macaque
nuclear receptor corepressor 1
Mouse
Dog
nuclear receptor corepressor 1
Horse
nuclear receptor corepressor 1
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75376-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (70)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 44
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Circadian Clock
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Chromatin modifying enzymes
Chromatin organization
Circadian Clock
Gene Ontology Terms (31)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (410)
1 – 10 of 410
TBL1Y
Tbio
p_int: 0.999997922
p_ni: 0.000002078
Data Source: BioPlex
GPS2
Tbio
Novelty: 0.00986158
p_int: 0.999997548
p_ni: 0.000002452
Score: 0.979
Data Source: BioPlex,Reactome,STRINGDB
HNRNPLL
Tbio
Novelty: 0.0498467
p_int: 0.995936546
p_ni: 0.004063454
Score: 0.273
Data Source: BioPlex,STRINGDB
C6orf141
Tdark
Novelty: 1.46022784
p_int: 0.995403793
p_ni: 0.004596207
Data Source: BioPlex
ZNF276
Tdark
Family: TF
Novelty: 0.3082638
p_int: 0.994814293
p_ni: 0.005185707
Score: 0.185
Data Source: BioPlex,STRINGDB
CDC16
Tbio
Novelty: 0.00916715
p_int: 0.980703842
p_ni: 0.019296158
Score: 0.162
Data Source: BioPlex,STRINGDB
IL17RA
Tclin
Novelty: 0.00416706
p_int: 0.976624405
p_ni: 0.023375595
Data Source: BioPlex
DGKG
Tbio
Family: Enzyme
Novelty: 0.03666646
p_int: 0.974334536
p_ni: 0.025665464
Data Source: BioPlex
ZSCAN5A
Tdark
Family: TF
Novelty: 2.15267128
p_int: 0.958432126
p_ni: 0.041567874
Score: 0.294
Data Source: BioPlex,STRINGDB
NCAPH2
Tbio
Novelty: 0.12134933
p_int: 0.921713722
p_ni: 0.078286278
Data Source: BioPlex
Publication Statistics
PubMed Score  415.80

PubMed score by year
PubTator Score  301.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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