Protein Classes
Protein Summary
Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variant ...more
- ENST00000295956
- ENSP00000295956
- ENSG00000136068
- ENST00000358537
- ENSP00000351339
- ENST00000429972
- ENSP00000415599
- ENST00000490882
- ENSP00000420213
- FLN1L
- FLN3
- TABP
- TAP
- AOI
- FH1
- SCT
- TAP
- LRS1
- TABP
- FLN-B
- FLN1L
- ABP-278
- ABP-280
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
transcription factor perturbation | 1 | ||
PubMedID | 0.95 | ||
protein domain | 0.92 | ||
transcription factor binding site profile | 0.92 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 167.74 (req: < 5)
Gene RIFs: 36 (req: <= 3)
Antibodies: 246 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 167.74 (req: >= 5)
Gene RIFs: 36 (req: > 3)
Antibodies: 246 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte count | 6 | 4 | 6 | 75.2 | |||||
neutrophil count | 2 | 2 | 2 | 73.6 | |||||
myeloid white cell count | 1 | 1 | 1 | 72.9 | |||||
reticulocyte measurement | 3 | 3 | 3 | 70.1 | |||||
optic cup area measurement | 3 | 2 | 3 | 65.9 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte count | 6 | 75.2 | |||||
neutrophil count | 2 | 73.6 | |||||
myeloid white cell count | 1 | 72.9 | |||||
reticulocyte measurement | 3 | 70.1 | |||||
optic cup area measurement | 3 | 65.9 | |||||
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | filamin B | VGNC:6265 | 460476 | |||||
Macaque | filamin B | 702732 | ||||||
Mouse | MGI:2446089 | 286940 | ||||||
Rat | RGD:1311915 | 306204 | ||||||
Dog | filamin B | VGNC:40901 | 484713 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | filamin B | |||||
Macaque | filamin B | |||||
Mouse | ||||||
Rat | ||||||
Dog | filamin B | |||||
Protein Data Bank (23)
1 – 5 of 23
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (16)
Reactome (5)
KEGG (4)
PathwayCommons (3)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Antiviral mechanism by IFN-stimulated genes | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | ISG15 antiviral mechanism | ||||
Reactome | Immune System | ||||
Reactome | Interferon Signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Antiviral mechanism by IFN-stimulated genes | ||||
Cytokine Signaling in Immune system | ||||
ISG15 antiviral mechanism | ||||
Immune System | ||||
Interferon Signaling | ||||
Gene Ontology Terms (23)
Functions (4)
Components (12)
Processes (7)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Protein-Protein Interactions (121)
1 – 10 of 121
LAD1
Novelty: 0.03059679
p_int: 0.999967706
p_ni: 0.000032294
Data Source: BioPlex
NUDT5
Family: Enzyme
Novelty: 0.02550535
p_int: 0.999513872
p_ni: 0.000486129
Score: 0.272
Data Source: BioPlex,STRINGDB
FBLIM1
Novelty: 0.0332985
p_int: 0.997258608
p_ni: 0.002741393
Score: 0.989
Data Source: BioPlex,STRINGDB
HSPB7
Novelty: 0.03344805
p_int: 0.993285059
p_ni: 0.006714941
Score: 0.579
Data Source: BioPlex,STRINGDB
ARRB2
Novelty: 0.00148149
p_int: 0.975386631
p_ni: 0.024613369
Score: 0.203
Data Source: BioPlex,STRINGDB
FLNA
Novelty: 0.00156479
Score: 0.97
Data Source: STRINGDB
ISG15
Novelty: 0.00203781
Score: 0.948
Data Source: Reactome,STRINGDB
UBE2L6
Novelty: 0.03471633
Score: 0.944
Data Source: Reactome,STRINGDB
ITGB1
Novelty: 0.00055626
Score: 0.942
Data Source: STRINGDB
ITGB3
Novelty: 0.00067255
Score: 0.929
Data Source: STRINGDB
Publication Statistics
PubMed Score 167.74
PubMed score by year
PubTator Score 168.07
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
GWAS Trait