Tbio FLNB Filamin-B

Protein Summary

Description

Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]

Uniprot Accession IDs

• O75369
• B2ZZ83
• B2ZZ84
• B2ZZ85
• C9JKE6
• C9JMC4
• Q13706
• Q59EC2
• Q60FE7
• Q6MZJ1
• Q8WXS9
• Q8WXT0
• Q8WXT1
• Q8WXT2
• Q8WXT3
• Q9NRB5
• Q9NT26
• Q9UEV9
• FLN-B

Gene Name

• FLNB

Ensembl ID

• ENST00000295956
• ENSP00000295956
• ENSG00000136068
• ENST00000358537
• ENSP00000351339
• ENST00000429972
• ENSP00000415599
• ENST00000490882
• ENSP00000420213

Symbol

• FLN1L
• FLN3
• TABP
• TAP
• AOI
• FH1
• SCT
• TAP
• LRS1
• TABP
• FLN-B
• FLN1L
• ABP-278
• ABP-280

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
transcription factor perturbation	1
PubMedID	0.95
protein domain	0.92
transcription factor binding site profile	0.92

Protein Classes

DTO Classes

Filamin-binding Lim Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 277.98   (req: < 5)

Gene RIFs: 47   (req: <= 3)

Antibodies: 246   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 277.98   (req: >= 5)

Gene RIFs: 47   (req: > 3)

Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0