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Tbio
H2AFY
Core histone macro-H2A.1

Protein Summary
Description
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription (PubMed:12718888, PubMed:15621527, PubMed:16428466). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation (PubMed:15897469). Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes (PubMed:12718888, PubMed:16428466). Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin (PubMed:16428466, PubMed:16107708). Isoform 1: Binds ADP-ribose and O-acetyl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304332
  • ENSP00000302572
  • ENSG00000113648
  • ENST00000312469
  • ENSP00000310169
  • ENST00000510038
  • ENSP00000424971
  • ENST00000511689
  • ENSP00000423563

Symbol
  • MACROH2A1
  • H2A.y
  • H2A/y
  • mH2A1
  • H2AF12M
  • MACROH2A1.1
  • macroH2A1.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
molecular function
0.99
cellular component
0.91
biological process
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.14   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.14   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
2
3
88.3
monocyte count
1
1
1
51.8
myeloid white cell count
1
1
1
43.5
lymphocyte percentage of leukocytes
1
1
1
36
mean platelet volume
1
1
1
34.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
88.3
monocyte count
1
51.8
myeloid white cell count
1
43.5
lymphocyte percentage of leukocytes
1
36
mean platelet volume
1
34.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
H2A histone family member Y
VGNC:4025
462076
Macaque
H2A histone family, member Y
711836
Mouse
MGI:1349392
26914
Rat
RGD:621462
29384
Dog
core histone macro-H2A.1
481514
Species
Name
OMA
EggNOG
Inparanoid
Chimp
H2A histone family member Y
Macaque
H2A histone family, member Y
Mouse
Rat
Dog
core histone macro-H2A.1
Protein Structure (12 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75367-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (20)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Systemic lupus erythematosus
KEGG
Necroptosis
KEGG
Alcoholism
Name
Explore in Pharos
Explore in Source
Systemic lupus erythematosus
Necroptosis
Alcoholism
Gene Ontology Terms (45)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (184)
1 – 10 of 184
H2AFY2
Tbio
Novelty: 0.09948698
p_int: 0.999999718
p_ni: 2.82e-7
Score: 0.766
Data Source: BioPlex,STRINGDB
H2BFWT
Tbio
Novelty: 0.16138632
p_int: 0.999839838
p_ni: 0.000160162
Score: 0.944
Data Source: BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty: 0.02431803
p_int: 0.999682694
p_ni: 0.000317306
Score: 0.968
Data Source: BioPlex,STRINGDB
APLF
Tbio
Novelty: 0.01347476
p_int: 0.998253307
p_ni: 0.001746693
Score: 0.712
Data Source: BioPlex,STRINGDB
HIST1H4A
Tbio
Novelty: 0.00279614
p_int: 0.995846776
p_ni: 0.004152679
p_wrong: 5.45e-7
Score: 0.975
Data Source: BioPlex,STRINGDB
XPC
Tbio
Novelty: 0.00775175
p_int: 0.983541641
p_ni: 0.016419422
p_wrong: 0.000038937
Score: 0.731
Data Source: BioPlex,STRINGDB
HDGFL2
Tbio
Family: Epigenetic
Novelty: 0.11846257
p_int: 0.982802345
p_ni: 0.017197654
p_wrong: 1e-9
Data Source: BioPlex
HMGN4
Tdark
Novelty: 0.01498794
p_int: 0.982117302
p_ni: 0.017882689
p_wrong: 9e-9
Data Source: BioPlex
CDK15
Tchem
Family: Kinase
Novelty: 0.3870338
p_int: 0.977198274
p_ni: 0.022800988
p_wrong: 7.38e-7
Score: 0.192
Data Source: BioPlex,STRINGDB
HSD3B2
Tclin
Family: Enzyme
Novelty: 0.00711552
p_int: 0.968854238
p_ni: 0.031145762
Score: 0.166
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  108.14

PubMed score by year
PubTator Score  32.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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