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Tchem
PTP4A3
Protein tyrosine phosphatase type IVA 3

Protein Summary
Description
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329397
  • ENSP00000332274
  • ENSG00000184489
  • ENST00000349124
  • ENSP00000331730
  • ENST00000520105
  • ENSP00000428758
  • ENST00000521578
  • ENSP00000428976
  • ENST00000614325
  • ENSP00000481205
  • ENSG00000275575
  • ENST00000622569
  • ENSP00000484500
  • ENST00000633518
  • ENSP00000487595
  • ENST00000633621
  • ENSP00000487610

Symbol
  • PRL3
  • PRL3
  • PRL-3
  • PRL-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
virus perturbation
0.88
biological term
0.84
tissue sample
0.7
cell type or tissue
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.65   (req: < 5)
Gene RIFs: 136   (req: <= 3)
Antibodies: 342   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.65   (req: >= 5)
Gene RIFs: 136   (req: > 3)
Antibodies: 342   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (46)
PTP4A2
Tchem
Family:  Enzyme
Novelty:  0.0083639
p_int:  0.755070932
p_ni:  9.9e-8
p_wrong:  0.244928969
Score:  0.396
Data Source:  BioPlex,STRINGDB
CNNM3
Tbio
Novelty:  0.13988333
Score:  0.972
Data Source:  STRINGDB
BCAR1
Tbio
Novelty:  0.00329214
Score:  0.962
Data Source:  STRINGDB
ITGB1
Tclin
Novelty:  0.00055626
Score:  0.944
Data Source:  STRINGDB
RHOC
Tbio
Family:  Enzyme
Novelty:  0.00262213
Score:  0.928
Data Source:  STRINGDB
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.924
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.92
Data Source:  STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.911
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.908
Data Source:  STRINGDB
TUBA1B
Tchem
Novelty:  0.02465964
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
3
3
91.8
neutrophil count
3
3
3
91.8
myeloid white cell count
2
2
2
82.9
myeloid white cell count
2
2
2
82.9
leukocyte count
2
2
2
81.4
Items per page:
1 – 5 of 24
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
91.8
neutrophil count
3
91.8
myeloid white cell count
2
82.9
myeloid white cell count
2
82.9
leukocyte count
2
81.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase type IVA, member 3
VGNC:50317
737820
Macaque
protein tyrosine phosphatase type IVA, member 3
693703
Mouse
MGI:1277098
19245
Rat
RGD:1308687
362930
Dog
protein tyrosine phosphatase type IVA, member 3
VGNC:45163
606961
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase type IVA, member 3
Macaque
protein tyrosine phosphatase type IVA, member 3
Mouse
Rat
Dog
protein tyrosine phosphatase type IVA, member 3
Publication Statistics
PubMed Score 129.65
PubMed score by year
PubTator Score 157.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title