Tchem PTP4A3 Protein tyrosine phosphatase type IVA 3

Protein Summary

Description

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• O75365
• Q8IVN5
• Q99849
• Q9BTW5

Gene Name

• PTP4A3

Ensembl ID

• ENST00000329397
• ENSP00000332274
• ENSG00000184489
• ENST00000349124
• ENSP00000331730
• ENST00000520105
• ENSP00000428758
• ENST00000521578
• ENSP00000428976
• ENST00000614325
• ENSP00000481205
• ENSG00000275575
• ENST00000622569
• ENSP00000484500
• ENST00000633518
• ENSP00000487595
• ENST00000633621
• ENSP00000487610

Symbol

• PRL3
• PRL3
• PRL-3
• PRL-R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.88
virus perturbation	0.88
biological term	0.84
tissue sample	0.7
cell type or tissue	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.48   (req: < 5)

Gene RIFs: 159   (req: <= 3)

Antibodies: 342   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.48   (req: >= 5)

Gene RIFs: 159   (req: > 3)

Antibodies: 342   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1