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Tbio
PITX3
Pituitary homeobox 3

Protein Summary
Description
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370002
  • ENSP00000359019
  • ENSG00000107859
  • ENST00000539804
  • ENSP00000439383

Symbol
  • PTX3
  • ASMD
  • ASOD
  • PTX3
  • ASGD1
  • CTPP4
  • CTRCT11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
protein domain
0.73
histone modification site profile
0.71
kinase perturbation
0.66
transcription factor
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.35   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.35   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
75.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
75.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
paired like homeodomain 3
VGNC:7250
466189
Mouse
MGI:1100498
18742
Rat
RGD:3332
29609
Dog
paired like homeodomain 3
VGNC:44591
486856
Horse
paired like homeodomain 3
VGNC:21480
100060046
Species
Name
OMA
EggNOG
Inparanoid
Chimp
paired like homeodomain 3
Mouse
Rat
Dog
paired like homeodomain 3
Horse
paired like homeodomain 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75364-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (27)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (72)
1 – 10 of 72
PITX2
Tbio
Family: TF
Novelty: 0.00216568
Score: 0.963
Data Source: STRINGDB
NR4A2
Tchem
Family: NR
Novelty: 0.00204712
Score: 0.893
Data Source: STRINGDB
TH
Tclin
Family: Enzyme
Novelty: 0.00025719
Score: 0.816
Data Source: STRINGDB
FOXE3
Tbio
Family: TF
Novelty: 0.02254278
Score: 0.785
Data Source: STRINGDB
GDNF
Tbio
Novelty: 0.00036702
Score: 0.718
Data Source: STRINGDB
FOXA2
Tbio
Family: TF
Novelty: 0.00244521
Score: 0.709
Data Source: STRINGDB
CRYAA2
Tdark
Novelty: 0.01914081
Score: 0.681
Data Source: STRINGDB
CRYAA
Tbio
Novelty: 0.01914081
Score: 0.681
Data Source: STRINGDB
SLC18A2
Tclin
Family: Transporter
Novelty: 0.00072341
Score: 0.679
Data Source: STRINGDB
GJA3
Tbio
Novelty: 0.00638283
Score: 0.679
Data Source: STRINGDB
Publication Statistics
PubMed Score  192.35

PubMed score by year
PubTator Score  88.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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