PITX3
Pituitary homeobox 3
Protein Summary
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens ...more
- ENST00000370002
- ENSP00000359019
- ENSG00000107859
- ENST00000539804
- ENSP00000439383
- PTX3
- ASMD
- ASOD
- PTX3
- ASGD1
- CTPP4
- CTRCT11
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.76 | ||
protein domain | 0.73 | ||
histone modification site profile | 0.71 | ||
kinase perturbation | 0.66 | ||
transcription factor | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 194.33 (req: < 5)
Gene RIFs: 38 (req: <= 3)
Antibodies: 182 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 194.33 (req: >= 5)
Gene RIFs: 38 (req: > 3)
Antibodies: 182 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 25
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (72)
Nearest Tclin Targets
Pathways (1)
WikiPathways (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
WikiPathways | Dopaminergic Neurogenesis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Dopaminergic Neurogenesis | ||||
Viral Interactions (0)
Gene Ontology Terms (27)
Functions (5)
Components (2)
Processes (20)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Disease Associations ()
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
intelligence | 4 | 4 | 3 | 7.3 | 87.9 | ||||
mathematical ability | 3 | 2 | 3 | 87.4 | |||||
self reported educational attainment | 4 | 2 | 3 | 7.3 | 85.7 | ||||
mean corpuscular volume | 1 | 1 | 1 | 77.9 | |||||
cognitive function measurement | 3 | 2 | 3 | 70.8 | |||||
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
intelligence | 3 | 7.3 | 87.9 | ||||
mathematical ability | 3 | 87.4 | |||||
self reported educational attainment | 3 | 7.3 | 85.7 | ||||
mean corpuscular volume | 1 | 77.9 | |||||
cognitive function measurement | 3 | 70.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | paired like homeodomain 3 | VGNC:7250 | 466189 | |||||
Mouse | MGI:1100498 | 18742 | ||||||
Rat | RGD:3332 | 29609 | ||||||
Dog | paired like homeodomain 3 | VGNC:44591 | 486856 | |||||
Horse | paired like homeodomain 3 | VGNC:21480 | 100060046 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | paired like homeodomain 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | paired like homeodomain 3 | |||||
Horse | paired like homeodomain 3 | |||||
Publication Statistics
PubMed Score 194.33
PubMed score by year
PubTator Score 88.40
PubTator score by year
Related Publications
Text Mined References (47)
GeneRif Annotations (38)
Items per page:
0 of 0
PMID | Year | Title |
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