Tbio PITX3 Pituitary homeobox 3

Protein Summary

Description

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity). This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development. Mutations of this gene have been associated with anterior segment mesenchymal dysgenesis and congenital cataracts. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75364
• Q5VZL2

Gene Name

• PITX3

Ensembl ID

• ENST00000370002
• ENSP00000359019
• ENSG00000107859
• ENST00000539804
• ENSP00000439383

Symbol

• PTX3
• ASMD
• ASOD
• PTX3
• ASGD1
• CTPP4
• CTRCT11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.76
protein domain	0.73
histone modification site profile	0.71
kinase perturbation	0.66
transcription factor	0.65

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.35   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 182   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.35   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	2	1	2		75.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	2		75.6

Reset Zoom  Beta Count   Odds Ratio

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	paired like homeodomain 3	VGNC:7250	466189
Mouse	paired-like homeodomain transcription factor 3	MGI:1100498	18742
Rat	paired-like homeodomain 3	RGD:3332	29609
Dog	paired like homeodomain 3	VGNC:44591	486856
Horse	paired like homeodomain 3	VGNC:21480	100060046

Species	Name	OMA	EggNOG	Inparanoid
Chimp	paired like homeodomain 3
Mouse	paired-like homeodomain transcription factor 3
Rat	paired-like homeodomain 3
Dog	paired like homeodomain 3
Horse	paired like homeodomain 3

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-O75364-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (1)

WikiPathways (1)

Find Similar Targets

Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
WikiPathways	Dopaminergic Neurogenesis	146 targets	WP2855_r105572

Name	Explore in Pharos	Explore in Source
Dopaminergic Neurogenesis	146 targets	WP2855_r105572

Gene Ontology Terms (27)

Functions (5)

Components (2)

Processes (20)

Find Similar Targets

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
RNA polymerase II transcription factor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
sequence-specific DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB

Protein-Protein Interactions (72)

Explore Interacting Targets

1 – 10 of 72

• See Interactions on String-DB

PITX2

Tbio

Family: TF

Novelty: 0.00216568

Score: 0.963

Data Source: STRINGDB

NR4A2

Tchem

Family: NR

Novelty: 0.00204712

Score: 0.893

Data Source: STRINGDB

TH

Tclin

Family: Enzyme

Novelty: 0.00025719

Score: 0.816

Data Source: STRINGDB

FOXE3

Tbio

Family: TF

Novelty: 0.02254278

Score: 0.785

Data Source: STRINGDB

GDNF

Tbio

Novelty: 0.00036702

Score: 0.718

Data Source: STRINGDB

FOXA2

Tbio

Family: TF

Novelty: 0.00244521

Score: 0.709

Data Source: STRINGDB

CRYAA2

Tdark

Novelty: 0.01914081

Score: 0.681

Data Source: STRINGDB

CRYAA

Tbio

Novelty: 0.01914081

Score: 0.681

Data Source: STRINGDB

SLC18A2

Tclin

Family: Transporter

Novelty: 0.00072341

Score: 0.679

Data Source: STRINGDB

GJA3

Tbio

Novelty: 0.00638283

Score: 0.679

Data Source: STRINGDB

Publication Statistics

PubMed Score  192.35

PubMed score by year

Reset Zoom

PubTator Score  88.4

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

Activator
Cataract
Complete proteome
Developmental protein
Disease mutation
DNA-binding
Homeobox
Nucleus
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

sex hormone-binding globulin measurement

MGI Phenotype Find Similar Targets

adipose tissue phenotype
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype