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Tbio
ZNF217
Zinc finger protein 217

Protein Summary
Description
Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302342
  • ENSP00000304308
  • ENSG00000171940
  • ENST00000371471
  • ENSP00000360526

Symbol
  • ZABC1
  • ZABC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
virus perturbation
0.85
microRNA
0.75
cell line
0.66
ligand (protein) perturbation
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.91   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 282   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.91   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 282   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
79.5
Eczema
1
1
0
1.1
79.4
red blood cell density measurement
1
1
1
76.7
lymphocyte count
2
2
2
72.7
sex hormone-binding globulin measurement
1
1
1
69.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
79.5
Eczema
0
1.1
79.4
red blood cell density measurement
1
76.7
lymphocyte count
2
72.7
sex hormone-binding globulin measurement
1
69.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 217
VGNC:6304
469974
Macaque
zinc finger protein 217
699314
Mouse
MGI:2685408
228913
Rat
RGD:1308451
311764
Dog
zinc finger protein 217
VGNC:48674
485934
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 217
Macaque
zinc finger protein 217
Mouse
Rat
Dog
zinc finger protein 217
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75362-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
ESR-mediated signaling (R-HSA-8939211)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Signal Transduction
Reactome
Signaling by Nuclear Receptors
Name
Explore in Pharos
Explore in Source
ESR-mediated signaling
Estrogen-dependent gene expression
Signal Transduction
Signaling by Nuclear Receptors
Gene Ontology Terms (14)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (136)
1 – 10 of 136
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
p_int: 0.999999993
p_ni: 4e-9
p_wrong: 4e-9
Score: 0.965
Data Source: BioPlex,STRINGDB
CTBP1
Tbio
Novelty: 0.00243818
p_int: 0.999999978
p_ni: 2.2e-8
Score: 0.881
Data Source: BioPlex,STRINGDB
PIPOX
Tbio
Family: Enzyme
Novelty: 0.04107707
p_int: 0.999879696
p_ni: 0.000120274
p_wrong: 3e-8
Score: 0.587
Data Source: BioPlex,STRINGDB
ESR1
Tclin
Family: NR
Novelty: 0.00005938
Score: 0.965
Data Source: Reactome,STRINGDB
HDAC2
Tclin
Family: Epigenetic
Novelty: 0.0011024
Score: 0.964
Data Source: STRINGDB
NCOA3
Tbio
Family: Epigenetic
Novelty: 0.00193529
Score: 0.947
Data Source: Reactome,STRINGDB
RBBP7
Tbio
Novelty: 0.01795364
Score: 0.931
Data Source: STRINGDB
PHF21A
Tbio
Family: Epigenetic
Novelty: 0.05904464
Score: 0.93
Data Source: STRINGDB
SIN3A
Tbio
Novelty: 0.00747207
Score: 0.929
Data Source: STRINGDB
MTA2
Tbio
Family: TF
Novelty: 0.01525806
Score: 0.927
Data Source: STRINGDB
Publication Statistics
PubMed Score  81.91

PubMed score by year
PubTator Score  67.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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