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Tbio
ENTPD3
Ectonucleoside triphosphate diphosphohydrolase 3

Protein Summary
Description
Has a threefold preference for the hydrolysis of ATP over ADP. This gene encodes a plasma membrane-bound divalent cation-dependent E-type nucleotidase. The encoded protein is involved in the regulation of extracellular levels of ATP by hydrolysis of it and other nucleotides. Multiple transcript variants have been described. [provided by RefSeq, May 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301825
  • ENSP00000301825
  • ENSG00000168032
  • ENST00000445129
  • ENSP00000404671
  • ENST00000456402
  • ENSP00000401565

Symbol
  • CD39L3
  • HB6
  • CD39L3
  • NTPDase-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
histone modification site profile
0.68
gene perturbation
0.55
disease
0.52
microRNA
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.84   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 250   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.84   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (213)
1 – 10 of 213
ENPP3
Tchem
Family:  Enzyme
Novelty:  0.00414129
Score:  0.969
Data Source:  STRINGDB
ENPP1
Tchem
Family:  Enzyme
Novelty:  0.00256132
Score:  0.968
Data Source:  STRINGDB
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
Score:  0.946
Data Source:  STRINGDB
PNPT1
Tbio
Family:  Enzyme
Novelty:  0.00339969
Score:  0.937
Data Source:  STRINGDB
UCK1
Tbio
Family:  Kinase
Novelty:  0.10536869
Score:  0.937
Data Source:  STRINGDB
DTYMK
Tbio
Family:  Kinase
Novelty:  0.00746576
Score:  0.925
Data Source:  STRINGDB
TK2
Tchem
Family:  Kinase
Novelty:  0.10642442
Score:  0.923
Data Source:  STRINGDB
UCK2
Tbio
Family:  Kinase
Novelty:  0.02417595
Score:  0.921
Data Source:  STRINGDB
ADK
Tchem
Family:  Kinase
Novelty:  0.00196435
Score:  0.92
Data Source:  STRINGDB
RRM1
Tclin
Family:  Enzyme
Novelty:  0.00083196
Score:  0.92
Data Source:  STRINGDB
Pathways (11)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Phosphate bond hydrolysis by NTPDase proteins
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Phosphate bond hydrolysis by NTPDase proteins
Gene Ontology Terms (15)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
1
1
33.1
1
1
0
1.1
17.8
parental genotype effect measurement
1
1
1
17.8
birth weight
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
33.1
0
1.1
17.8
parental genotype effect measurement
1
17.8
birth weight
1
17.8
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ectonucleoside triphosphate diphosphohydrolase 3
VGNC:1807
460286
Macaque
ectonucleoside triphosphate diphosphohydrolase 3
718311
Mouse
MGI:1321386
215446
Rat
RGD:631326
316077
Dog
ectonucleoside triphosphate diphosphohydrolase 3
VGNC:40382
485604
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ectonucleoside triphosphate diphosphohydrolase 3
Macaque
ectonucleoside triphosphate diphosphohydrolase 3
Mouse
Rat
Dog
ectonucleoside triphosphate diphosphohydrolase 3
Publication Statistics
PubMed Score 64.84
PubMed score by year
PubTator Score 28.54
PubTator score by year