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Tbio
FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

Protein Summary
Description
Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity). The protein encoded by this gene is a cis-trans peptidyl-prolyl isomerase that may function in immunoregulation and basic cellular processes involving protein folding and trafficking. This gene is located in a chromosomal region that is deleted in Williams-Beuren syndrome. Defects in this gene m ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252037
  • ENSP00000252037
  • ENSG00000077800
  • ENST00000413573
  • ENSP00000394952
  • ENST00000431982
  • ENSP00000416277

Symbol
  • FKBP36
  • FKBP36
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.76
tissue sample
0.64
cell type or tissue
0.63
protein domain
0.58
cellular component
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.72   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 251   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.72   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
26.6
triglyceride measurement
1
1
1
16.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
26.6
triglyceride measurement
1
16.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FK506 binding protein 6
VGNC:4358
472404
Macaque
FK506 binding protein 6
716306
Mouse
MGI:2137612
94244
Rat
RGD:1308926
288597
Dog
FK506 binding protein 6
VGNC:40892
489810
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FK506 binding protein 6
Macaque
FK506 binding protein 6
Mouse
Rat
Dog
FK506 binding protein 6
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75344-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Gene Silencing by RNA
Reactome
Gene expression (Transcription)
Reactome
Meiosis
Reactome
Meiotic synapsis
Name
Explore in Pharos
Explore in Source
Cell Cycle
Gene Silencing by RNA
Gene expression (Transcription)
Meiosis
Meiotic synapsis
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (160)
1 – 10 of 160
OSBP
Tbio
Novelty: 0.00425747
p_int: 0.999999635
p_ni: 3.65e-7
Score: 0.176
Data Source: BioPlex,STRINGDB
CDC37L1
Tbio
Novelty: 0.11043692
p_int: 0.999998677
p_ni: 0.000001053
p_wrong: 2.69e-7
Score: 0.311
Data Source: BioPlex,STRINGDB
AGAP3
Tbio
Family: Enzyme
Novelty: 0.15649084
p_int: 0.999989061
p_ni: 0.000010939
Score: 0.213
Data Source: BioPlex,STRINGDB
EEF2K
Tchem
Family: Kinase
Novelty: 0.02271177
p_int: 0.999969701
p_ni: 6e-9
p_wrong: 0.000030293
Score: 0.288
Data Source: BioPlex,STRINGDB
PPP1R12A
Tbio
Family: Enzyme
Novelty: 0.0028297
p_int: 0.999966025
p_ni: 0.000033975
Score: 0.192
Data Source: BioPlex,STRINGDB
HSP90AA5P
Tdark
p_int: 0.999949374
p_ni: 0.000050626
Data Source: BioPlex
PPP1R12B
Tbio
Family: Enzyme
Novelty: 0.0424259
p_int: 0.99989813
p_ni: 5e-9
p_wrong: 0.000101865
Score: 0.297
Data Source: BioPlex,STRINGDB
USP19
Tbio
Family: Enzyme
Novelty: 0.04078253
p_int: 0.999686494
p_ni: 0.000313506
Score: 0.353
Data Source: BioPlex,STRINGDB
IK
Tbio
Novelty: 0.01510642
p_int: 0.998390313
p_ni: 0.001609687
Score: 0.225
Data Source: BioPlex,STRINGDB
WDCP
Tdark
Novelty: 0.29184907
p_int: 0.996405924
p_ni: 0.003594076
Data Source: BioPlex
Publication Statistics
PubMed Score  40.72

PubMed score by year
PubTator Score  13.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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