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Tbio
ALOX12B
Arachidonate 12-lipoxygenase, 12R-type

Protein Summary
Description
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12R)-hydroperoxyeicosatetraenoic acid/(12R)-HPETE and minor stereoisomers. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins. This gene encodes an enzyme involved in the conversion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma. [provided by RefSeq, Sep 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319144
  • ENSP00000315167
  • ENSG00000179477
  • ENST00000647874
  • ENSP00000497784

Symbol
  • ARCI2
  • 12R-LOX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
gene perturbation
0.8
biological process
0.75
molecular function
0.53
trait
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.86   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.86   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
CCDC51
Tdark
Novelty:  1.19203634
p_int:  0.995684976
p_ni:  0.004315023
p_wrong:  2e-9
Data Source:  BioPlex
ZIC1
Tbio
Family:  TF
Novelty:  0.00491601
p_int:  0.994106513
p_ni:  0.005893487
Data Source:  BioPlex
ZSCAN12
Tdark
Family:  TF
Novelty:  0.33578207
p_int:  0.980878607
p_ni:  0.019121393
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.976417165
p_ni:  0.023582835
Data Source:  BioPlex
FTH1
Tbio
Novelty:  0.000863
p_int:  0.964740329
p_ni:  0.035259671
Data Source:  BioPlex
CCDC103
Tbio
Novelty:  0.07857649
p_int:  0.958547833
p_ni:  0.041452167
Data Source:  BioPlex
NPPA
Tchem
Novelty:  0.00046693
p_int:  0.950092619
p_ni:  0.049907381
Data Source:  BioPlex
DPPA4
Tbio
Novelty:  0.05764302
p_int:  0.949991514
p_ni:  0.050008486
Data Source:  BioPlex
AIRE
Tbio
Family:  TF; Epigenetic
Novelty:  0.00158659
p_int:  0.918632508
p_ni:  0.081367491
Score:  0.183
Data Source:  BioPlex,STRINGDB
UBE3A
Tbio
Family:  Enzyme
Novelty:  0.00149368
p_int:  0.892246499
p_ni:  0.107753501
Data Source:  BioPlex
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
1 – 3 of 3
Pathways (11)
Arachidonic acid metabolism (R-HSA-2142753)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of 12-eicosatetraenoic acid derivatives
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Fatty acid metabolism
Metabolism
Metabolism of lipids
Synthesis of 12-eicosatetraenoic acid derivatives
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
3
2
1.1
88.6
diastolic blood pressure
1
1
1
49.5
high density lipoprotein cholesterol measurement
1
1
1
49.5
body height
1
1
1
11.8
mathematical ability
2
1
2
11.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
1.1
88.6
diastolic blood pressure
1
49.5
high density lipoprotein cholesterol measurement
1
49.5
body height
1
11.8
mathematical ability
2
11.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arachidonate 12-lipoxygenase, 12R type
VGNC:10346
455103
Mouse
MGI:1274782
11686
Rat
RGD:1305330
287425
Dog
arachidonate 12-lipoxygenase, 12R type
VGNC:37810
489486
Horse
arachidonate 12-lipoxygenase, 12R type
VGNC:15261
100062323
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arachidonate 12-lipoxygenase, 12R type
Mouse
Rat
Dog
arachidonate 12-lipoxygenase, 12R type
Horse
arachidonate 12-lipoxygenase, 12R type
Publication Statistics
PubMed Score 39.86
PubMed score by year
PubTator Score 32.44
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title