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Tbio
PDCD6
Programmed cell death protein 6

Protein Summary
Description
Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair. Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes (PubMed:20691033, PubMed:25667979). Involved in ER-Golgi transport by promoting the association between PDCD6IP and TSG101, thereby bridging together the ESCRT-III and ESCRT-I complexes (PubMed:19520058). Together with PEF1, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in ER-Golgi transport by regulating the size of COPII coats (PubMed:27716508). In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264933
  • ENSP00000264933
  • ENSG00000249915
  • ENST00000505221
  • ENSP00000422085
  • ENST00000507528
  • ENSP00000423815

Symbol
  • ALG2
  • ALG2
  • ALG-2
  • PEF1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.96
cellular component
0.95
kinase perturbation
0.95
co-expressed gene
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.79   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 297   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.79   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 297   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (37)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (117)
1 – 10 of 117
SEC31A
Tbio
Novelty: 0.06064315
Score: 0.995
Data Source: STRINGDB
PEF1
Tbio
Novelty: 0.02707214
Score: 0.978
Data Source: STRINGDB
SEC31B
Tdark
Novelty: 0.83333333
Score: 0.976
Data Source: STRINGDB
SEC13
Tbio
Novelty: 0.0100577
Score: 0.957
Data Source: STRINGDB
SEC24B
Tbio
Novelty: 0.01524602
Score: 0.939
Data Source: STRINGDB
SEC23A
Tbio
Novelty: 0.0358158
Score: 0.936
Data Source: STRINGDB
KLHL12
Tbio
Novelty: 0.10348863
Score: 0.928
Data Source: STRINGDB
SEC24A
Tbio
Novelty: 0.14959041
Score: 0.923
Data Source: STRINGDB
SAR1A
Tbio
Family: Enzyme
Novelty: 0.07402125
Score: 0.921
Data Source: STRINGDB
SEC24C
Tbio
Novelty: 0.09004427
Score: 0.914
Data Source: STRINGDB
Publication Statistics
PubMed Score  68.79

PubMed score by year
PubTator Score  24.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer