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Tbio
TBX10
T-box transcription factor TBX10

Protein Summary
Description
Probable transcriptional regulator involved in developmental processes. This gene encodes a member of the T-box family of transcription factors. These transcription factors share a DNA-binding domain called the T-box, and play a role in several developmental processes including early embryonic cell fate and organogenesis. The encoded protein is a member of the T-box 1 subfamily. Mutations in this gene are thought to be a cause of isolated cleft lip with or without cleft palate. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335385
  • ENSP00000335191
  • ENSG00000167800

Symbol
  • TBX7
  • TBX7
  • TBX13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.6
phenotype
0.54
tissue
0.52
biological process
0.43
protein domain
0.41


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.67   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.67   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
2
4
6
91.8
BMI-adjusted hip circumference
2
4
4
85.2
urinary metabolite measurement
1
1
1
51.4
BMI-adjusted waist-hip ratio
1
1
1
21.5
serum metabolite measurement
1
1
1
21.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
6
91.8
BMI-adjusted hip circumference
4
85.2
urinary metabolite measurement
1
51.4
BMI-adjusted waist-hip ratio
1
21.5
serum metabolite measurement
1
21.2
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
T-box 10
VGNC:13384
746047
Mouse
MGI:1261436
109575
Rat
RGD:1584144
688822
Dog
T-box 10
VGNC:49658
611811
Horse
T-box 10 [Source:HGNC Symbol;Acc:HGNC:11593]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
T-box 10
Mouse
Rat
Dog
T-box 10
Horse
T-box 10 [Source:HGNC Symbol;Acc:HGNC:11593]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75333-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (37)
1 – 10 of 37
VANGL2
Tbio
Novelty:  0.00529796
Score:  0.588
Data Source:  STRINGDB
LHX8
Tbio
Family:  TF
Novelty:  0.01815234
Score:  0.569
Data Source:  STRINGDB
FOXE1
Tbio
Family:  TF
Novelty:  0.00783938
Score:  0.549
Data Source:  STRINGDB
ISL1
Tbio
Family:  TF
Novelty:  0.00169431
Score:  0.53
Data Source:  STRINGDB
HMX1
Tbio
Family:  TF
Novelty:  0.03754742
Score:  0.515
Data Source:  STRINGDB
NKX2-3
Tbio
Family:  TF
Novelty:  0.02138156
Score:  0.514
Data Source:  STRINGDB
WNT11
Tbio
Novelty:  0.0045754
Score:  0.493
Data Source:  STRINGDB
ACY3
Tbio
Family:  Enzyme
Novelty:  0.08834946
Score:  0.49
Data Source:  STRINGDB
MSX1
Tbio
Family:  TF
Novelty:  0.00176212
Score:  0.488
Data Source:  STRINGDB
ZNF202
Tbio
Family:  TF
Novelty:  0.06306212
Score:  0.48
Data Source:  STRINGDB
Publication Statistics
PubMed Score  6.67

PubMed score by year
PubTator Score  2.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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