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Tchem
HMMR
Hyaluronan mediated motility receptor

Protein Summary
Description
Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity). The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353866
  • ENSP00000185942
  • ENSG00000072571
  • ENST00000358715
  • ENSP00000351554
  • ENST00000393915
  • ENSP00000377492
  • ENST00000432118
  • ENSP00000402673

Symbol
  • IHABP
  • RHAMM
  • CD168
  • IHABP
  • RHAMM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.91
transcription factor perturbation
0.91
histone modification site profile
0.9
PubMedID
0.88
transcription factor binding site profile
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 295.59   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 411   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 295.59   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 411   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (299)
BACH1
Tbio
Family:  TF
Novelty:  0.04011328
p_int:  0.999999951
p_ni:  4.4e-8
p_wrong:  5e-9
Score:  0.562
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999998566
p_ni:  0.000001434
Data Source:  BioPlex
FAM83D
Tbio
Novelty:  0.07381559
p_int:  0.999995397
p_ni:  0.000004603
Score:  0.971
Data Source:  BioPlex,STRINGDB
CCDC40
Tbio
Novelty:  0.06726469
p_int:  0.999994004
p_ni:  0.000005996
Score:  0.222
Data Source:  BioPlex,STRINGDB
HMG20A
Tbio
Family:  TF
Novelty:  0.11994252
p_int:  0.999980954
p_ni:  0.000019046
Data Source:  BioPlex
CSNK1A1
Tchem
Family:  Kinase
Novelty:  0.00636472
p_int:  0.999811436
p_ni:  0.000188563
p_wrong:  1e-9
Score:  0.619
Data Source:  BioPlex,STRINGDB
IL17RE
Tbio
Novelty:  0.07568341
p_int:  0.999700188
p_ni:  0.000299812
Score:  0.169
Data Source:  BioPlex,STRINGDB
GMNN
Tbio
Novelty:  0.00436572
p_int:  0.999646624
p_ni:  0.000353372
p_wrong:  4e-9
Score:  0.674
Data Source:  BioPlex,STRINGDB
NMD3
Tbio
Novelty:  0.03505289
p_int:  0.999358877
p_ni:  0.000641123
Score:  0.561
Data Source:  BioPlex,STRINGDB
WDR36
Tbio
Novelty:  0.02010676
p_int:  0.999347547
p_ni:  0.000652453
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
G2/M Transition
Reactome
Glycosaminoglycan metabolism
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Cell Cycle
Cell Cycle, Mitotic
G2/M Transition
Glycosaminoglycan metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
1
3
60.5
metabolite measurement
1
1
1
1.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
60.5
metabolite measurement
1
1.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hyaluronan mediated motility receptor
VGNC:6934
737973
Macaque
hyaluronan mediated motility receptor
697991
Mouse
MGI:104667
15366
Rat
RGD:2805
25460
Dog
hyaluronan mediated motility receptor
VGNC:41718
611838
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hyaluronan mediated motility receptor
Macaque
hyaluronan mediated motility receptor
Mouse
Rat
Dog
hyaluronan mediated motility receptor
Publication Statistics
PubMed Score 295.59
PubMed score by year
PubTator Score 159.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title