Tchem HMMR Hyaluronan mediated motility receptor

Protein Summary

Description

Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity). The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008]

Uniprot Accession IDs

• O75330
• A8K3G2
• B4E114
• D3DQK9
• D3DQL0
• E9PCS0
• Q32N02
• Q92767

Gene Name

• HMMR

Ensembl ID

• ENST00000353866
• ENSP00000185942
• ENSG00000072571
• ENST00000358715
• ENSP00000351554
• ENST00000393915
• ENSP00000377492
• ENST00000432118
• ENSP00000402673

Symbol

• IHABP
• RHAMM
• CD168
• IHABP
• RHAMM

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.91
transcription factor perturbation	0.91
histone modification site profile	0.9
PubMedID	0.88
transcription factor binding site profile	0.77

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 337.8   (req: < 5)

Gene RIFs: 82   (req: <= 3)

Antibodies: 411   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 337.8   (req: >= 5)

Gene RIFs: 82   (req: > 3)

Antibodies: 411   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0