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Tbio
SEMA7A
Semaphorin-7A

Protein Summary
Description
Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261918
  • ENSP00000261918
  • ENSG00000138623
  • ENST00000543145
  • ENSP00000438966

Symbol
  • CD108
  • SEMAL
  • JMH
  • CD108
  • SEMAL
  • CDw108
  • SEMAK1
  • H-Sema-L
  • H-SEMA-K1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
disease perturbation
0.87
biological process
0.84
PubMedID
0.69
cell type or tissue
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.36   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 378   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.36   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 378   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
40.6
apolipoprotein A 1 measurement
1
1
1
35
high density lipoprotein cholesterol measurement
1
1
1
32
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
40.6
apolipoprotein A 1 measurement
1
35
high density lipoprotein cholesterol measurement
1
32
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
semaphorin 7A
VGNC:6586
467824
Macaque
semaphorin 7A (John Milton Hagen blood group)
702185
Mouse
MGI:1306826
20361
Rat
RGD:1305192
315711
Dog
semaphorin 7A (John Milton Hagen blood group)
487644
Species
Name
OMA
EggNOG
Inparanoid
Chimp
semaphorin 7A
Macaque
semaphorin 7A (John Milton Hagen blood group)
Mouse
Rat
Dog
semaphorin 7A (John Milton Hagen blood group)
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75326-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Other semaphorin interactions
Reactome
Semaphorin interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Other semaphorin interactions
Semaphorin interactions
Gene Ontology Terms (25)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (103)
1 – 10 of 103
SOAT1
Tchem
Family: Enzyme
Novelty: 0.00530755
p_int: 0.999968505
p_ni: 0.000031495
Data Source: BioPlex
DPY19L1
Tdark
Family: Enzyme
Novelty: 0.34765717
p_int: 0.999795039
p_ni: 0.000204283
p_wrong: 6.78e-7
Score: 0.183
Data Source: BioPlex,STRINGDB
UNC93B1
Tbio
Novelty: 0.01288921
p_int: 0.999720777
p_ni: 0.000239286
p_wrong: 0.000039937
Score: 0.271
Data Source: BioPlex,STRINGDB
CLEC4A
Tbio
Novelty: 0.01821643
p_int: 0.999267562
p_ni: 0.000726079
p_wrong: 0.000006359
Data Source: BioPlex
TAPT1
Tbio
Novelty: 0.12057711
p_int: 0.999054682
p_ni: 0.000470088
p_wrong: 0.00047523
Score: 0.256
Data Source: BioPlex,STRINGDB
TMEM214
Tdark
Novelty: 0.32604613
p_int: 0.998795086
p_ni: 0.001204913
p_wrong: 1e-9
Data Source: BioPlex
CKAP4
Tbio
Novelty: 0.02104039
p_int: 0.998588278
p_ni: 0.001411722
Data Source: BioPlex
TMEM39B
Tdark
Novelty: 3.99024108
p_int: 0.99432854
p_ni: 0.005671456
p_wrong: 4e-9
Score: 0.165
Data Source: BioPlex,STRINGDB
SLC9A1
Tchem
Family: Transporter
Novelty: 0.00096678
p_int: 0.979177091
p_ni: 0.011573362
p_wrong: 0.009249548
Score: 0.172
Data Source: BioPlex,STRINGDB
SLC12A9
Tdark
Family: Transporter
Novelty: 0.12936696
p_int: 0.974666645
p_ni: 0.025333354
p_wrong: 1e-9
Score: 0.159
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  147.36

PubMed score by year
PubTator Score  49.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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