Tbio SEMA7A Semaphorin-7A

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Semaphorin-7a

DTO Classes

Protein / Signaling / Membrane-bound Signaling Molecule / Semaphorin-7a

Protein Summary

Description

Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• O75326
• B4DDP7
• F5H1S0
• Q1XE81
• Q1XE82
• Q1XE83
• Q1XE84
• Q3MIY5

Gene Name

• SEMA7A

Ensembl ID

• ENST00000261918
• ENSP00000261918
• ENSG00000138623
• ENST00000543145
• ENSP00000438966

Symbol

• CD108
• SEMAL
• JMH
• CD108
• SEMAL
• CDw108
• SEMAK1
• H-Sema-L
• H-SEMA-K1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
disease perturbation	0.87
biological process	0.84
PubMedID	0.69
cell type or tissue	0.68

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.36   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 378   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.36   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 378   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hypertension	EFO_0000537	1	1	1		40.6
apolipoprotein A 1 measurement	EFO_0004614	1	1	1		35
high density lipoprotein cholesterol measurement	EFO_0004612	1	1	1		32

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hypertension	EFO_0000537	1		40.6
apolipoprotein A 1 measurement	EFO_0004614	1		35
high density lipoprotein cholesterol measurement	EFO_0004612	1		32

Reset Zoom  Beta Count   Odds Ratio

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	semaphorin 7A	VGNC:6586	467824
Macaque	semaphorin 7A (John Milton Hagen blood group)		702185
Mouse	sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A	MGI:1306826	20361
Rat	semaphorin 7A (John Milton Hagen blood group)	RGD:1305192	315711
Dog	semaphorin 7A (John Milton Hagen blood group)		487644

Species	Name	OMA	EggNOG	Inparanoid
Chimp	semaphorin 7A
Macaque	semaphorin 7A (John Milton Hagen blood group)
Mouse	sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
Rat	semaphorin 7A (John Milton Hagen blood group)
Dog	semaphorin 7A (John Milton Hagen blood group)

Protein Structure (1 Structure, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75326-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (5)

Reactome (4)

KEGG (1)

Axon guidance (R-HSA-422475)

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Find Similar Targets

Items per page:

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Other semaphorin interactions	19 targets	R-HSA-416700
Reactome	Semaphorin interactions	64 targets	R-HSA-373755

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Developmental Biology	1055 targets	R-HSA-1266738
Other semaphorin interactions	19 targets	R-HSA-416700
Semaphorin interactions	64 targets	R-HSA-373755

Gene Ontology Terms (25)

Functions (4)

Components (6)

Processes (15)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
chemorepellent activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
integrin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
neuropilin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
semaphorin receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (103)

Explore Interacting Targets

1 – 10 of 103

• See Interactions on String-DB

SOAT1

Tchem

Family: Enzyme

Novelty: 0.00530755

p_int: 0.999968505

p_ni: 0.000031495

Data Source: BioPlex

DPY19L1

Tdark

Family: Enzyme

Novelty: 0.34765717

p_int: 0.999795039

p_ni: 0.000204283

p_wrong: 6.78e-7

Score: 0.183

Data Source: BioPlex,STRINGDB

UNC93B1

Tbio

Novelty: 0.01288921

p_int: 0.999720777

p_ni: 0.000239286

p_wrong: 0.000039937

Score: 0.271

Data Source: BioPlex,STRINGDB

CLEC4A

Tbio

Novelty: 0.01821643

p_int: 0.999267562

p_ni: 0.000726079

p_wrong: 0.000006359

Data Source: BioPlex

TAPT1

Tbio

Novelty: 0.12057711

p_int: 0.999054682

p_ni: 0.000470088

p_wrong: 0.00047523

Score: 0.256

Data Source: BioPlex,STRINGDB

TMEM214

Tdark

Novelty: 0.32604613

p_int: 0.998795086

p_ni: 0.001204913

p_wrong: 1e-9

Data Source: BioPlex

CKAP4

Tbio

Novelty: 0.02104039

p_int: 0.998588278

p_ni: 0.001411722

Data Source: BioPlex

TMEM39B

Tdark

Novelty: 3.99024108

p_int: 0.99432854

p_ni: 0.005671456

p_wrong: 4e-9

Score: 0.165

Data Source: BioPlex,STRINGDB

SLC9A1

Tchem

Family: Transporter

Novelty: 0.00096678

p_int: 0.979177091

p_ni: 0.011573362

p_wrong: 0.009249548

Score: 0.172

Data Source: BioPlex,STRINGDB

SLC12A9

Tdark

Family: Transporter

Novelty: 0.12936696

p_int: 0.974666645

p_ni: 0.025333354

p_wrong: 1e-9

Score: 0.159

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  147.36

PubMed score by year

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PubTator Score  49.74

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Cell membrane
Complete proteome
Developmental protein
Differentiation
Disulfide bond
Glycoprotein
GPI-anchor
Immunoglobulin domain

GWAS Trait Find Similar Targets

apolipoprotein A 1 measurement
high density lipoprotein cholesterol measurement
hypertension

MGI Phenotype Find Similar Targets

cellular phenotype
nervous system phenotype