Tdark SNN Stannin

Protein Summary

Description

Plays a role in the toxic effects of organotins (PubMed:15269288). Plays a role in endosomal maturation (PubMed:27015288).

Uniprot Accession IDs

• O75324
• D3DUG4
• Q6FGI0

Gene Name

• SNN

Ensembl ID

• ENST00000329565
• ENSP00000329287
• ENSG00000184602

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.84
PubMedID	0.7
virus perturbation	0.59
microRNA	0.58
protein domain	0.58

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.56   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 8   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.56   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Gene Ontology Terms (5)

Functions (1)

Components (3)

Processes (1)

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
metal ion binding	Inferred from Direct Assay (IDA)	CAFA

Protein-Protein Interactions (34)

Explore Interacting Targets

1 – 10 of 34

• See Interactions on String-DB

MTDH

Tbio

Novelty: 0.00211478

p_int: 0.999972217

p_ni: 0.000027783

Score: 0.309

Data Source: BioPlex,STRINGDB

TMX1

Tbio

Novelty: 0.01558923

p_int: 0.998035127

p_ni: 0.001964873

Score: 0.196

Data Source: BioPlex,STRINGDB

TES

Tbio

Novelty: 0.00112939

p_int: 0.997352366

p_ni: 0.002645344

p_wrong: 0.00000229

Score: 0.243

Data Source: BioPlex,STRINGDB

C1orf131

Tdark

p_int: 0.944091511

p_ni: 0.048354637

p_wrong: 0.007553852

Score: 0.282

Data Source: BioPlex,STRINGDB

FST

Tbio

Novelty: 0.00081807

Score: 0.785

Data Source: STRINGDB

SPIN4

Tdark

Novelty: 0.21428571

Score: 0.733

Data Source: STRINGDB

TXNDC11

Tbio

Novelty: 0.10709732

Score: 0.681

Data Source: STRINGDB

VIPR1

Tchem

Family: GPCR

Novelty: 0.00222991

Score: 0.652

Data Source: STRINGDB

ADAMTS3

Tbio

Family: Enzyme

Novelty: 0.00834011

Score: 0.646

Data Source: STRINGDB

YWHAZ

Tbio

Novelty: 0.00235606

Score: 0.621

Data Source: STRINGDB

Publication Statistics

PubMed Score  225.56

PubMed score by year

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PubTator Score  17.03

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MSIMDHSPTTGVVTVIVILIAIAALGALILGCWCYLRLQRISQSEDEESIVGDGETKEPFLLVQYSAKGP

1-70

CVERKAKLMTPNGPEVHG

70-88

MSIMDHSPTTGVVTVIVILIAIAALGALILGCWCYLRLQRISQSEDEESIVGDGETKEPFLLVQYSAKGPCVERKAKLMTPNGPEVHG

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Uniprot Keyword

3D-structure
Complete proteome
Membrane
Mitochondrion
Mitochondrion outer membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix