Tbio DUSP11 RNA/RNP complex-1-interacting phosphatase

Protein Summary

Description

Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism. The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]

Uniprot Accession IDs

• O75319
• B2RCT8
• C9JYA6
• Q6AI47
• Q9BWE3

Gene Name

• DUSP11

Ensembl ID

• ENST00000272444
• ENSP00000272444
• ENSG00000144048
• ENST00000443070
• ENSP00000413444

Symbol

• PIR1
• PIR1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
disease perturbation	0.74
molecular function	0.63
tissue sample	0.63
transcription factor binding site profile	0.62

Protein Classes

PANTHER Classes

Protein / Transferase / Nucleotidyltransferase / Rna/rnp Complex-1-interacting Phosphatase

Protein / Hydrolase / Phosphatase / Rna/rnp Complex-1-interacting Phosphatase

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Rna/rnp Complex-1-interacting Phosphatase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 104   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0