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Tbio
USP12
Ubiquitin carboxyl-terminal hydrolase 12

Protein Summary
Description
Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity (PubMed:19075014, PubMed:27373336). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014). In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282344
  • ENSP00000282344
  • ENSG00000152484

Symbol
  • UBH1
  • USP12L1
  • UBH1
  • USP12L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.8
microRNA
0.76
cell type or tissue
0.64
transcription factor
0.64
histone modification site profile
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.35   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.35   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0